Morphological characterization of rat entorhinal neurons in vivo: soma-dendritic structure and axonal domains.

Morphological characterization of rat entorhinal neurons in vivo: soma-dendritic structure and axonal domains. Research Abstract Details 

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Morphological characterization of rat entorhinal neurons in vivo: soma-dendritic structure and axonal domains. Abstract Text:

K Lingenhöhl,D M Finch,

We used in vivo intracellular labeling with horseradish peroxidase in order to study the soma-dendritic morphology and axonal projections of rat entorhinal neurons. The cells responded to hippocampal stimulation with inhibitory postsynaptic potentials, and thus likely received direct or indirect hippocampal input. All cells (n = 24) showed extensive dendritic domains that extended in some cases for more than 1 mm. The dendrites of layer II neurons were largely restricted to layers I and II or layers I-III, while the dendrites of deeper cells could extend through all cortical layers. Computed 3D rotations showed that the basilar dendrites of deep pyramids extended roughly parallel to the cortical layering, and that they were mostly confined to the layer containing the soma and layers immediately adjacent. Total dendritic lengths averaged 9.8 mm +/- 3.8 (SD), and ranged from 5 mm to more than 18 mm. Axonal processes could be visualized in 21 cells. Most of these showed axonal branching within the entorhinal cortex, sometimes extensive. Efferent axonal domains were reconstructed in detail in 3 layer II stellate cells. All 3 projected axons across the subicular complex to the dentate gyrus. One of these cells showed an extensive net-like axonal domain that also projected to several other structures, including the hippocampus proper, subicular complex, and the amygdalo-piriform transition area. The axons of layer III and IV cells projected to the angular bundle, where they continued in a rostral direction. In contrast to the layer II, III and IV cells, no efferent axonal branches leaving the entorhinal cortex could be visualized in 5 layer V neurons. The data indicate that entorhinal neurons can integrate input from a considerable volume of entorhinal cortex by virtue of their extensive dendritic domains, and provide a further basis for specifying the layers in which cells receive synaptic input. The extensive axonal branching pattern seen in most of the cells would support divergent propagation of their activity.

Morphological characterization of rat entorhinal neurons in vivo: soma-dendritic structure and axonal domains. Publishing Authors By Initials

K Lingenhöhl,DM Finch,

For similar nervous system: synapses research abstracts see: nervous system: synapses research

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Morphological characterization of rat entorhinal neurons in vivo: soma-dendritic structure and axonal domains. Journal Published:

PUBLICATION TYPE: Research Support, U.S. Gov't,

Journal: Experimental brain research. Experimentelle Hirnfo

VOLUME: 84

Page Numbers: 57-74

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ISSN: 0014-4819

DAY: 15

MONTH: 02

YEAR: 1991

Morphological characterization of rat entorhinal neurons in vivo: soma-dendritic structure and axonal domains. Information

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LANGUAGE: eng

NlmUniqueID: 43312

Morphological characterization of rat entorhinal neurons in vivo: soma-dendritic structure and axonal domains. Keywords Mesh Terms:

KEYWORDS: Synapses

MESH TERMS: ultrastructure

Chemical & Substance for Abstract: Morphological characterization of rat entorhinal neurons in vivo: soma-dendritic structure and axonal domains. Information

Substance Name: Horseradish Peroxidase

Registry Number: EC 1.11.1.-

Grant and Affiliation Information for Morphological characterization of rat entorhinal neurons in vivo: soma-dendritic structure and axonal domains.

AFFILIATION: Brain Research Institute, Los Angeles, CA 90024.

Country: GERMANY

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MEDLINETA: Exp Brain Res

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