Morphine modulates gammadelta lymphocytes cytolytic activity following BCG vaccination.

Morphine modulates gammadelta lymphocytes cytolytic activity following BCG vaccination. Research Abstract Details 

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Morphine modulates gammadelta lymphocytes cytolytic activity following BCG vaccination. Abstract Text:

Michael R Olin,Keumhwa Choi,Jinhee Lee,Phillip K Peterson,Thomas W Molitor,

Chronic opioid administration modulates lymphocytes' functional capabilities increasing susceptibility to infectious diseases. Bacille-Calmette-Guérin (BCG) vaccination initiates a non-specific and specific cell-mediated immunity orchestrated by T lymphocytes including gammadelta T lymphocytes. gammadelta T lymphocytes increase in natural killer and antigen-directed cytolytic response following BCG vaccination. The objective of this study was to determine morphine effects on gammadelta T lymphocytes' cytolytic activity. Pigs were chronically administered morphine and subsequently vaccinated with Mycobacterium bovis BCG. By administering morphine prior to BCG vaccination, natural killer response was significantly suppressed (p=.034). Furthermore, innate cytolytic response against M. bovis-infected monocytes (p=.002) as well as antigen specific cytolytic functions (p=.04) were significantly altered due to morphine administration. It was concluded that administering morphine prior to BCG vaccination significantly altered gammadelta T lymphocyte cytolytic responses.

Morphine modulates gammadelta lymphocytes cytolytic activity following BCG vaccination. Publishing Authors By Initials

MR Olin,K Choi,J Lee,PK Peterson,TW Molitor,

For similar cells: blood cells: leukocytes: leukocytes, mononuclear: lymphocytes: t-lymphocytes: cd8-positive t-lymphocytes: t-lymphocytes, cytotoxic research abstracts see: cells: blood cells: leukocytes: leukocytes, mononuclear: lymphocytes: t-lymphocytes: cd8-positive t-lymphocytes: t-lymphocytes, cytotoxic research

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Morphine modulates gammadelta lymphocytes cytolytic activity following BCG vaccination. Journal Published:

PUBLICATION TYPE: Research Support, N.I.H., Extr

Journal: Brain, behavior, and immunity

VOLUME: 21

Page Numbers: 195-201

Journal Abbreviation: Brain Behav. Immun.

ISSN: 0889-1591

DAY: 25

MONTH: 07

YEAR: 2006

Morphine modulates gammadelta lymphocytes cytolytic activity following BCG vaccination. Information

Number of References:

LANGUAGE: eng

NlmUniqueID: 8800478

Morphine modulates gammadelta lymphocytes cytolytic activity following BCG vaccination. Keywords Mesh Terms:

KEYWORDS: T-Lymphocytes, Cytotoxic

MESH TERMS: immunology

Chemical & Substance for Abstract: Morphine modulates gammadelta lymphocytes cytolytic activity following BCG vaccination. Information

Substance Name: Morphine

Registry Number: 57-27-2

Grant and Affiliation Information for Morphine modulates gammadelta lymphocytes cytolytic activity following BCG vaccination.

AFFILIATION: University of Minnesota, Veterinary Population Medicine, College of Veterinary Medicine, 1365 Gortner Ave., St. Paul, MN 55108, USA.

Country: United States

AGENCY: United States NIDA

GRANT: T32 DA07097

ACRONYM: DA

MEDLINETA: Brain Behav Immun

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