Mornings with Art, lessons learned: feedback regulation, restriction threshold biology, and redundancy govern molecular stress responses.

Mornings with Art, lessons learned: feedback regulation, restriction threshold biology, and redundancy govern molecular stress responses. Research Abstract Details 

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Mornings with Art, lessons learned: feedback regulation, restriction threshold biology, and redundancy govern molecular stress responses. Abstract Text:

Erik A Bey,Shelly M Wuerzberger-Davis,John J Pink,Chin-Rang Yang,Shinako Araki,Kathryn E Reinicke,Melissa S Bentle,Ying Dong,Eva Cataldo,Tracy L Criswell,Mark W Wagner,Longshan Li,Jinming Gao,David A Boothman,

Work from the laboratory of Dr. Arthur B. Pardee has highlighted basic principles that govern cellular and molecular biological processes in living cells. Among the most important governing principles in cellular and molecular responses are: (i) threshold "restriction" responses, wherein a level of response is reached and a "point of no return" is achieved; (ii) feedback regulation; and (iii) redundancy. Lessons learned from the molecular biology of cellular stress responses in mammalian cancer versus normal cells after ionizing radiation (IR) or chemotherapeutic agent exposures reveal similar instances of these guiding principles in mammalian cells. Among these are the: (i) induction of cell death responses by beta-lapachone (beta-lap), a naphthoquinone anti-tumor agent that kills cancer cells via an NQO1 (i.e., X-ray-inducible protein-3, xip3)-dependent mechanism; (ii) induction of secretory clusterin (sCLU) in response to TGF-beta1 exposure, and the ability of induced sCLU protein to down-regulate TGF-beta1 signaling; and (iii) induction of DNA mismatch repair-dependent G(2) cell cycle checkpoint responses after exposure to alkylating agents. We have learned these lessons and now adopted strategies to exploit them for improved therapy. These examples will be discussed and compared to the pioneering findings of researchers in the Pardee laboratory over the years.

Mornings with Art, lessons learned: feedback regulation, restriction threshold biology, and redundancy govern molecular stress responses. Publishing Authors By Initials

EA Bey,SM Wuerzberger-Davis,JJ Pink,CR Yang,S Araki,KE Reinicke,MS Bentle,Y Dong,E Cataldo,TL Criswell,MW Wagner,L Li,J Gao,DA Boothman,

For similar chemical actions and uses: pharmacologic actions: physiological effects of drugs: radiation-sensitizing agents research abstracts see: chemical actions and uses: pharmacologic actions: physiological effects of drugs: radiation-sensitizing agents research

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Mornings with Art, lessons learned: feedback regulation, restriction threshold biology, and redundancy govern molecular stress responses. Journal Published:

PUBLICATION TYPE: Review

Journal: Journal of cellular physiology

VOLUME: 209

Page Numbers: 604-10

Journal Abbreviation: J. Cell. Physiol.

ISSN: 0021-9541

DAY: 3

MONTH: Dec

YEAR: 2006

Mornings with Art, lessons learned: feedback regulation, restriction threshold biology, and redundancy govern molecular stress responses. Information

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LANGUAGE: eng

NlmUniqueID: 50222

Mornings with Art, lessons learned: feedback regulation, restriction threshold biology, and redundancy govern molecular stress responses. Keywords Mesh Terms:

KEYWORDS: Radiation-Sensitizing Agents

MESH TERMS: therapeutic use

Chemical & Substance for Abstract: Mornings with Art, lessons learned: feedback regulation, restriction threshold biology, and redundancy govern molecular stress responses. Information

Substance Name: beta-lapachone

Registry Number: 4707-32-8

Grant and Affiliation Information for Mornings with Art, lessons learned: feedback regulation, restriction threshold biology, and redundancy govern molecular stress responses.

AFFILIATION: Laboratory of Molecular Stress Responses, Department of Pharmacology and Simmons Comprehensive Cancer Center, University of Texas Southwestern Medical Center at Dallas, 5323 Harry Hines Boulevard, Dallas, TX 75390, USA.

Country: United States

AGENCY: United States NCI

GRANT: 1R01 CA 102792-01

ACRONYM: CA

MEDLINETA: J Cell Physiol

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