More is not always better: increased fractional anisotropy of superior longitudinal fasciculus associated with poor visuospatial abilities in Williams syndrome.

More is not always better: increased fractional anisotropy of superior longitudinal fasciculus associated with poor visuospatial abilities in Williams syndrome. Research Abstract Details 

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More is not always better: increased fractional anisotropy of superior longitudinal fasciculus associated with poor visuospatial abilities in Williams syndrome. Abstract Text:

Fumiko Hoeft,Naama Barnea-Goraly,Brian W Haas,Golijeh Golarai,Derek Ng,Debra Mills,Julie Korenberg,Ursula Bellugi,Albert Galaburda,Allan L Reiss,

We used diffusion tensor imaging to examine white matter integrity in the dorsal and ventral streams among individuals with Williams syndrome (WS) compared with two control groups (typically developing and developmentally delayed) and using three separate analysis methods (whole brain, region of interest, and fiber tractography). All analysis methods consistently showed that fractional anisotropy (FA; a measure of microstructural integrity) was higher in the right superior longitudinal fasciculus (SLF) in WS compared with both control groups. There was a significant association with deficits in visuospatial construction and higher FA in WS individuals. Comparable increases in FA across analytic methods were not observed in the left SLF or the bilateral inferior longitudinal fasciculus in WS subjects. Together, these findings suggest a specific role of right SLF abnormality in visuospatial construction deficits in WS.

More is not always better: increased fractional anisotropy of superior longitudinal fasciculus associated with poor visuospatial abilities in Williams syndrome. Publishing Authors By Initials

F Hoeft,N Barnea-Goraly,BW Haas,G Golarai,D Ng,D Mills,J Korenberg,U Bellugi,A Galaburda,AL Reiss,

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More is not always better: increased fractional anisotropy of superior longitudinal fasciculus associated with poor visuospatial abilities in Williams syndrome. Journal Published:

PUBLICATION TYPE: Research Support, N.I.H., Extr

Journal: The Journal of neuroscience : the official journal

VOLUME: 27

Page Numbers: 11960-5

Journal Abbreviation: J. Neurosci.

ISSN: 1529-2401

DAY: 31

MONTH: Oct

YEAR: 2007

More is not always better: increased fractional anisotropy of superior longitudinal fasciculus associated with poor visuospatial abilities in Williams syndrome. Information

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LANGUAGE: eng

NlmUniqueID: 8102140

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AFFILIATION: Center for Interdisciplinary Brain Sciences Research, Department of Psychiatry and Behavioral Sciences, Stanford University School of Medicine, Palo Alto, California 94305-5795, USA. fumiko@stanford.edu

Country: United States

AGENCY: United States NICHD

GRANT: P01 HD033113-12

ACRONYM: HD

MEDLINETA: J Neurosci

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