Mop3 is an essential component of the master circadian pacemaker in mammals.

Mop3 is an essential component of the master circadian pacemaker in mammals. Research Abstract Details 

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Mop3 is an essential component of the master circadian pacemaker in mammals. Abstract Text:

M K Bunger,L D Wilsbacher,S M Moran,C Clendenin,L A Radcliffe,J B Hogenesch,M C Simon,J S Takahashi,C A Bradfield,

Circadian oscillations in mammalian physiology and behavior are regulated by an endogenous biological clock. Here we show that loss of the PAS protein MOP3 (also known as BMAL1) in mice results in immediate and complete loss of circadian rhythmicity in constant darkness. Additionally, locomotor activity in light-dark (LD) cycles is impaired and activity levels are reduced in Mop3-/- mice. Analysis of Period gene expression in the suprachiasmatic nucleus (SCN) indicates that these behavioral phenotypes arise from loss of circadian function at the molecular level. These results provide genetic evidence that MOP3 is the bona fide heterodimeric partner of mCLOCK. Furthermore, these data demonstrate that MOP3 is a nonredundant and essential component of the circadian pacemaker in mammals.

Mop3 is an essential component of the master circadian pacemaker in mammals. Publishing Authors By Initials

MK Bunger,LD Wilsbacher,SM Moran,C Clendenin,LA Radcliffe,JB Hogenesch,MC Simon,JS Takahashi,CA Bradfield,

For similar proteins: transcription factors research abstracts see: proteins: transcription factors research

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Mop3 is an essential component of the master circadian pacemaker in mammals. Journal Published:

PUBLICATION TYPE: Research Support, U.S. Gov't,

Journal: Cell

VOLUME: 103

Page Numbers: 1009-17

Journal Abbreviation: Cell

ISSN: 0092-8674

DAY: 22

MONTH: Dec

YEAR: 2000

Mop3 is an essential component of the master circadian pacemaker in mammals. Information

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LANGUAGE: eng

NlmUniqueID: 413066

Mop3 is an essential component of the master circadian pacemaker in mammals. Keywords Mesh Terms:

KEYWORDS: Transcription Factors

MESH TERMS: metabolism

Chemical & Substance for Abstract: Mop3 is an essential component of the master circadian pacemaker in mammals. Information

Substance Name: Transcription Factors

Registry Number: 0

Grant and Affiliation Information for Mop3 is an essential component of the master circadian pacemaker in mammals.

AFFILIATION: The McArdle Laboratory for Cancer Research, University of Wisconsin Medical School, Madison, WI 53706, USA.

Country: United States

AGENCY: United States NCI

GRANT: P30-CA07175

ACRONYM: CA

MEDLINETA: Cell

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