Monoclonal antibody studies on the properties and regulation of murine ornithine decarboxylase antizymes.

Monoclonal antibody studies on the properties and regulation of murine ornithine decarboxylase antizymes. Research Abstract Details 

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Monoclonal antibody studies on the properties and regulation of murine ornithine decarboxylase antizymes. Abstract Text:

S Matsufuji,R Kanamoto,Y Murakami,S Hayashi,

Seven monoclonal antibodies were prepared against rat liver ornithine decarboxylase antizyme, a unique regulatory protein of the enzyme induced by its products. The monoclonal antibodies reacted with antizymes from all the rat and mouse tissues examined, indicating that these antizymes share similar structural features, though some size heterogeneity has been reported for rat antizymes. A sandwich enzyme immunoassay which could detect 0.1 ng of antizyme was developed using these antibodies. The amount of antizyme protein in rat liver, analyzed by the immunoassay, increased on putrescine treatment in parallel with antizyme activity, indicating that the changes in antizyme activity were attributable to the changes in the amount of its protein. The putrescine-induced increase of antizyme protein, as well as that of its activity, was completely inhibited by cycloheximide but not by actinomycin D, confirming the importance of post-transcriptional regulation in antizyme induction.

Monoclonal antibody studies on the properties and regulation of murine ornithine decarboxylase antizymes. Publishing Authors By Initials

S Matsufuji,R Kanamoto,Y Murakami,S Hayashi,

For similar animals: animal population groups: animals, inbred strains: rats, inbred strains research abstracts see: animals: animal population groups: animals, inbred strains: rats, inbred strains research

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Monoclonal antibody studies on the properties and regulation of murine ornithine decarboxylase antizymes. Journal Published:

PUBLICATION TYPE: Research Support, Non-U.S. Gov

Journal: Journal of biochemistry

VOLUME: 107

Page Numbers: 87-91

Journal Abbreviation: J. Biochem.

ISSN: 0021-924X

DAY: 19

MONTH: Jan

YEAR: 1990

Monoclonal antibody studies on the properties and regulation of murine ornithine decarboxylase antizymes. Information

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LANGUAGE: eng

NlmUniqueID: 376600

Monoclonal antibody studies on the properties and regulation of murine ornithine decarboxylase antizymes. Keywords Mesh Terms:

KEYWORDS: Rats, Inbred Strains

MESH TERMS: pharmacology

Chemical & Substance for Abstract: Monoclonal antibody studies on the properties and regulation of murine ornithine decarboxylase antizymes. Information

Substance Name: Ornithine Decarboxylase

Registry Number: EC 4.1.1.17

Grant and Affiliation Information for Monoclonal antibody studies on the properties and regulation of murine ornithine decarboxylase antizymes.

AFFILIATION: Department of Nutrition, Jikei University School of Medicine, Tokyo.

Country: JAPAN

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MEDLINETA: J Biochem

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