Monoclonal antibodies to the human mammary gland. II. Distribution of determinants in breast carcinomas.

Monoclonal antibodies to the human mammary gland. II. Distribution of determinants in breast carcinomas. Research Abstract Details 

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Monoclonal antibodies to the human mammary gland. II. Distribution of determinants in breast carcinomas. Abstract Text:

C S Foster,E A Dinsdale,P A Edwards,A M Neville,

A range of primary and metastatic human breast carcinomas has been examined with respect to the staining by four monoclonal antibodies which were raised to the human milk fat globule membrane. Within the normal breast the luminal epithelial cells expressing the antigens detected by the monoclonal antibodies were heterogeneous in their distribution. The heterogeneity was not only confined to single cells, but also to regions within the breast. The breast carcinomas also expressed the antigens in a variable manner. Morphological differentiation and functional differentiation, defined by the monoclonal antibodies, were not invariably coincident. Lymph node metastases gave similar results to the primary carcinomas. The monoclonal antibodies have revealed a heterogeneity, with respect to surface antigenic expression, within the normal and neoplastic breast epithelium. This cellular heterogeneity of breast carcinomas, may have significant prognostic and therapeutic implications in the management of primary breast cancer.

Monoclonal antibodies to the human mammary gland. II. Distribution of determinants in breast carcinomas. Publishing Authors By Initials

CS Foster,EA Dinsdale,PA Edwards,AM Neville,

For similar fluids and secretions: bodily secretions: milk, human research abstracts see: fluids and secretions: bodily secretions: milk, human research

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Monoclonal antibodies to the human mammary gland. II. Distribution of determinants in breast carcinomas. Journal Published:

PUBLICATION TYPE: Journal Article

Journal: Virchows Archiv. A, Pathological anatomy and histo

VOLUME: 394

Page Numbers: 295-305

Journal Abbreviation:

ISSN: 0340-1227

DAY: 20

MONTH: 02

YEAR: 1982

Monoclonal antibodies to the human mammary gland. II. Distribution of determinants in breast carcinomas. Information

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LANGUAGE: eng

NlmUniqueID: 7505137

Monoclonal antibodies to the human mammary gland. II. Distribution of determinants in breast carcinomas. Keywords Mesh Terms:

KEYWORDS: Milk, Human

MESH TERMS: analysis

Chemical & Substance for Abstract: Monoclonal antibodies to the human mammary gland. II. Distribution of determinants in breast carcinomas. Information

Substance Name: Lipids

Registry Number: 0

Grant and Affiliation Information for Monoclonal antibodies to the human mammary gland. II. Distribution of determinants in breast carcinomas.

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Country: GERMANY, WEST

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MEDLINETA: Virchows Arch A Pathol Anat Hi

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