Monoclonal antibodies in chronic lymphocytic leukemia.

Monoclonal antibodies in chronic lymphocytic leukemia. Research Abstract Details 

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Monoclonal antibodies in chronic lymphocytic leukemia. Abstract Text:

Alessandra Ferrajoli,Stefan Faderl,Michael J Keating,

Multiple options are now available for the treatment of chronic lymphocytic leukemia. Over the last 10 years, monoclonal antibodies have become an integral part of the management of this disease. Alemtuzumab has received approval for use in patients with fludarabine-refractory chronic lymphocytic leukemia. Rituximab has been investigated extensively in chronic lymphocytic leukemia both as a single agent and in combination with chemotherapy and other monoclonal antibodies. Epratuzumab and lumiliximab are newer monoclonal antibodies in the early phase of clinical development. This article will review the monoclonal antibodies more commonly used to treat chronic lymphocytic leukemia, the results obtained with monoclonal antibodies as single agents and in combination with chemotherapy, and other biological agents and newer compounds undergoing clinical trials.

Monoclonal antibodies in chronic lymphocytic leukemia. Publishing Authors By Initials

A Ferrajoli,S Faderl,MJ Keating,

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Monoclonal antibodies in chronic lymphocytic leukemia. Journal Published:

PUBLICATION TYPE: Review

Journal: Expert review of anticancer therapy

VOLUME: 6

Page Numbers: 1231-8

Journal Abbreviation: Expert Rev Anticancer Ther

ISSN: 1744-8328

DAY: 5

MONTH: Sep

YEAR: 2006

Monoclonal antibodies in chronic lymphocytic leukemia. Information

Number of References: 66

LANGUAGE: eng

NlmUniqueID: 101123358

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AFFILIATION: University of Texas MD Anderson Cancer Center, Department of Leukemia, Unit 428, PO Box 301402, Houston, TX 77230-1402, USA. aferrajo@mdanderson.org

Country: England

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MEDLINETA: Expert Rev Anticancer Ther

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