Monoamine oxidase inhibitor-responsive depression.

Monoamine oxidase inhibitor-responsive depression. Research Abstract Details 

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Monoamine oxidase inhibitor-responsive depression. Abstract Text:

Double-blind, placebo-controlled trials have documented the efficacy of some monoamine oxidase (MAO) inhibitors in treating certain depressed patients. This preliminary report of a 6-week, double-blind, placebo-controlled study of the MAO inhibitor isocarboxazid (Marplan) examines the time course of platelet MAO inhibition and treatment response, and describes symptoms that distinguish markedly improved from slightly improved responders. Thirty male outpatients, ages 28-64, randomly divided into placebo (n = 15) and active medication (n = 15) groups, were followed weekly. Medication was started at 20 mg daily and increased to achieve 90% platelet MAO inhibition. Data were analyzed for 24 patients who completed at least 3 weeks of the study. A clinician's global change rating at the study's conclusion showed that 12 of 13 patients (92%) in the active medication group improved, while 3 of 11 (27%) patients in the placebo group improved. Significant symptomatic improvement occurred in the active treatment group by week 3. Trends suggest that anxiety improved first (week 2), followed by depression (week 3), and finally cognitive outlook (week 6). Only minimal difficulties were observed with orthostatic hypotension, hypertensive crises, or other side effects. At baseline, the only significant difference between the markedly improved and slightly improved groups was greater psychomotor retardation in the markedly improved group. Trends suggest that the markedly improved group showed less depression, anxiety, sleep disturbance, and weight loss, fewer gastrointestinal complaints, and more helplessness and worthlessness.

Monoamine oxidase inhibitor-responsive depression. Publishing Authors By Initials

For similar behavioral disciplines and activities: psychiatric status rating scales research abstracts see: behavioral disciplines and activities: psychiatric status rating scales research

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MEDLINE DATE:

Monoamine oxidase inhibitor-responsive depression. Journal Published:

PUBLICATION TYPE: Research Support, U.S. Gov't,

Journal: Psychiatry research

VOLUME: 6

Page Numbers: 41-8

Journal Abbreviation: Psychiatry Res

ISSN: 0165-1781

DAY: 17

MONTH: Feb

YEAR: 1982

Monoamine oxidase inhibitor-responsive depression. Information

Number of References:

LANGUAGE: eng

NlmUniqueID: 7911385

Monoamine oxidase inhibitor-responsive depression. Keywords Mesh Terms:

KEYWORDS: Psychiatric Status Rating Scales

MESH TERMS: therapeutic use

Chemical & Substance for Abstract: Monoamine oxidase inhibitor-responsive depression. Information

Substance Name: Isocarboxazid

Registry Number: 59-63-2

Grant and Affiliation Information for Monoamine oxidase inhibitor-responsive depression.

AFFILIATION:

Country: NETHERLANDS

AGENCY: United States NIMH

GRANT: MH-30939

ACRONYM: MH

MEDLINETA: Psychiatry Res

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