Monitoring of singlet oxygen is useful for predicting the photodynamic effects in the treatment for experimental glioma.

Monitoring of singlet oxygen is useful for predicting the photodynamic effects in the treatment for experimental glioma. Research Abstract Details 

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Monitoring of singlet oxygen is useful for predicting the photodynamic effects in the treatment for experimental glioma. Abstract Text:

Junkoh Yamamoto,Seiji Yamamoto,Toru Hirano,Shaoyi Li,Masayo Koide,Eiji Kohno,Mitsuo Okada,Chikanori Inenaga,Tsutomu Tokuyama,Naoki Yokota,Susumu Terakawa,Hiroki Namba,

PURPOSE: Singlet oxygen ((1)O(2)) generated in photodynamic therapy (PDT) plays a very important role in killing tumor cells. Using a new near-IR photomultiplier tube system, we monitored the real-time production of (1)O(2) during PDT and thus investigated the relationship between the (1)O(2) production and photodynamic effects. EXPERIMENTAL DESIGN: We did PDT in 9L gliosarcoma cells in vitro and in an experimental tumor model in vivo using 5-aminolevulinic acid and nanosecond-pulsed dye laser. During this time, we monitored (1)O(2) using this system. Moreover, based on the (1)O(2) monitoring, we set the different conditions of laser exposure and investigated whether they could affect the tumor cell death. RESULTS: We could observe the temporal changes of (1)O(2) production during PDT in detail. At a low fluence rate the (1)O(2) signal gradually decreased with a low peak, whereas at a high fluence rate it decreased immediately with a high peak. Consequently, the cumulative (1)O(2) at a low fluence rate was higher, which thus induced a strong photodynamic effect. The proportion of apoptosis to necrosis might therefore be dependent on the peak and duration of the (1)O(2) signal. A low fluence rate tended to induce apoptotic change, whereas a high fluence rate tended to induce necrotic change. CONCLUSIONS: The results of this study suggested that the monitoring of (1)O(2) enables us to predict the photodynamic effect, allowing us to select the optimal laser conditions for each patient.

Monitoring of singlet oxygen is useful for predicting the photodynamic effects in the treatment for experimental glioma. Publishing Authors By Initials

J Yamamoto,S Yamamoto,T Hirano,S Li,M Koide,E Kohno,M Okada,C Inenaga,T Tokuyama,N Yokota,S Terakawa,H Namba,

For similar diagnosis: prognosis: treatment outcome research abstracts see: diagnosis: prognosis: treatment outcome research

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Monitoring of singlet oxygen is useful for predicting the photodynamic effects in the treatment for experimental glioma. Journal Published:

PUBLICATION TYPE: Research Support, Non-U.S. Gov

Journal: Clinical cancer research : an official journal of

VOLUME: 12

Page Numbers: 7132-9

Journal Abbreviation: Clin. Cancer Res.

ISSN: 1078-0432

DAY: 1

MONTH: Dec

YEAR: 2006

Monitoring of singlet oxygen is useful for predicting the photodynamic effects in the treatment for experimental glioma. Information

Number of References:

LANGUAGE: eng

NlmUniqueID: 9502500

Monitoring of singlet oxygen is useful for predicting the photodynamic effects in the treatment for experimental glioma. Keywords Mesh Terms:

KEYWORDS: Treatment Outcome

MESH TERMS: metabolism

Chemical & Substance for Abstract: Monitoring of singlet oxygen is useful for predicting the photodynamic effects in the treatment for experimental glioma. Information

Substance Name: Singlet Oxygen

Registry Number: 17778-80-2

Grant and Affiliation Information for Monitoring of singlet oxygen is useful for predicting the photodynamic effects in the treatment for experimental glioma.

AFFILIATION: Department of Neurosurgery and Photon Medical Research Center, Hamamatsu University School of Medicine, Hamamatsu, Japan.

Country: United States

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MEDLINETA: Clin Cancer Res

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