[Monitoring of antibiotic resistance of gram negative anaerobes.]

[Monitoring of antibiotic resistance of gram negative anaerobes.] Research Abstract Details 

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[Monitoring of antibiotic resistance of gram negative anaerobes.] Abstract Text:

MATERIAL AND METHOD: Using an agar reference method (Norma M11-A5, National Committee for Clinical and Laboratory Standards) the minimal inhibitory concentrations of nine antibiotics were determined for 376 anaerobic strains. The following strains were investigated: 254 Bacteroides fragilis group (including 143 B. fragilis), 122 other gram-negative anaerobes (Bacteroides spp., Prevotella, Fusobacterium, Porphyromonas, Suterella, Desulfomonas, Veillonella). RESULTS: In the B. fragilis group resistance rates were: coamoxyclav 2.8%, ticarcillin 27.5%, ticarcillin-clavulanic acid 1.9%, piperacillin-tazobactam 1.9%, cefoxitin 6.2%, imipenem 0.8%, clindamycin 28.3%, respectively. Based on previous studies, resistance to imipenem remained low in 2003 and was only observed for B. fragilis. Resistance to clindamycin was maintained around 25%. No metronidazole resistance was observed, but decreased susceptibility was found for B. fragilis, B. merdae and Prevotella, as in 4.3% of gram-negative anaerobes. DISCUSSION: This study confirms the high resistance rate of gram-negative anaerobes to clindamycin, the efficient activity of imipenem, beta-lactam/beta-lactamase inhibitor combinations and metronidazole. However, reduced metronidazole susceptibility seems to be increasing.

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[Monitoring of antibiotic resistance of gram negative anaerobes.] Journal Published:

PUBLICATION TYPE: Journal Article

Journal: Médecine et maladies infectieuses

VOLUME: 38

Page Numbers: 256-63

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ISSN: 0399-077X

DAY: 14

MONTH: 05

YEAR: 2008

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LANGUAGE: fre

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AFFILIATION: Laboratoire de bactériologie clinique, faculté des sciences pharmaceutiques et biologiques, 3, rue du Professeur-Laguesse, B.P. 83, 59006 Lille cedex, France.

Country: France

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MEDLINETA: Med Mal Infect

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