Molecular separation of two signaling pathways for the receptor, Notch.

Molecular separation of two signaling pathways for the receptor, Notch. Research Abstract Details 

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Molecular separation of two signaling pathways for the receptor, Notch. Abstract Text:

Maude Le Gall,Cordell De Mattei,Edward Giniger,

Notch is required for many aspects of cell fate specification and morphogenesis during development, including neurogenesis and axon guidance. We here provide genetic and biochemical evidence that Notch directs axon growth and guidance in Drosophila via a "non-canonical", i.e. non-Su(H)-mediated, signaling pathway, characterized by association with the adaptor protein, Disabled, and Trio, an accessory factor of the Abl tyrosine kinase. We find that forms of Notch lacking the binding sites for its canonical effector, Su(H), are nearly inactive for the cell fate function of the receptor, but largely or fully active in axon patterning. Conversely, deletion from Notch of the binding site for Disabled impairs its action in axon patterning without disturbing cell fate control. Finally, we show by co-immunoprecipitation that Notch protein is physically associated in vivo with both Disabled and Trio. Together, these data provide evidence for an alternate Notch signaling pathway that mediates a postmitotic, morphogenetic function of the receptor.

Molecular separation of two signaling pathways for the receptor, Notch. Publishing Authors By Initials

M Le Gall,C De Mattei,E Giniger,

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Molecular separation of two signaling pathways for the receptor, Notch. Journal Published:

PUBLICATION TYPE: Research Support, N.I.H., Intr

Journal: Developmental biology

VOLUME: 313

Page Numbers: 556-67

Journal Abbreviation: Dev. Biol.

ISSN: 1095-564X

DAY: 11

MONTH: 12

YEAR: 2007

Molecular separation of two signaling pathways for the receptor, Notch. Information

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LANGUAGE: eng

NlmUniqueID: 372762

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Grant and Affiliation Information for Molecular separation of two signaling pathways for the receptor, Notch.

AFFILIATION: Axon Guidance and Neural Connectivity Unit, Basic Neuroscience Program, National Institute of Neurological Disorders and Stroke (NINDS), National Institutes of Health, Bldg. 37, Rm. 1016, 37 Convent Drive, Bethesda, MD 20892, USA.

Country: United States

AGENCY: United States NIGMS

GRANT: GM57830

ACRONYM: GM

MEDLINETA: Dev Biol

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