Molecular regulation of pancreatic beta-cell mass development, maintenance, and expansion.

Molecular regulation of pancreatic beta-cell mass development, maintenance, and expansion. Research Abstract Details 

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Molecular regulation of pancreatic beta-cell mass development, maintenance, and expansion. Abstract Text:

Amanda M Ackermann,Maureen Gannon,

Pancreatic beta-cells are responsible for producing all of the insulin required by an organism to maintain glucose homeostasis. Defects in development, maintenance, or expansion of beta-cell mass can result in impaired glucose metabolism and diabetes. Thus, identifying the molecular regulators of these processes may provide new therapeutic targets for diabetes. Additionally, understanding the processes of beta-cell differentiation and proliferation may allow for in vitro cultivation of beta-cells in sufficient amounts to be transplanted into patients with diabetes. This review addresses many of the transcription factors and signaling pathways that play a role in early pancreatic development and endocrine cell (specifically beta-cell) differentiation, conditions that influence beta-cell mass development and molecular regulators of beta-cell proliferation and apoptosis that are responsible for maintaining and expanding beta-cell mass.

Molecular regulation of pancreatic beta-cell mass development, maintenance, and expansion. Publishing Authors By Initials

AM Ackermann,M Gannon,

For similar digestive system: pancreas research abstracts see: digestive system: pancreas research

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Molecular regulation of pancreatic beta-cell mass development, maintenance, and expansion. Journal Published:

PUBLICATION TYPE: Review

Journal: Journal of molecular endocrinology

VOLUME: 38

Page Numbers: 193-206

Journal Abbreviation: J. Mol. Endocrinol.

ISSN: 0952-5041

DAY: 3

MONTH: Feb

YEAR: 2007

Molecular regulation of pancreatic beta-cell mass development, maintenance, and expansion. Information

Number of References: 26

LANGUAGE: eng

NlmUniqueID: 8902617

Molecular regulation of pancreatic beta-cell mass development, maintenance, and expansion. Keywords Mesh Terms:

KEYWORDS: Pancreas

MESH TERMS: growth & development

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Grant and Affiliation Information for Molecular regulation of pancreatic beta-cell mass development, maintenance, and expansion.

AFFILIATION: Department of Medicine, Vanderbilt University Medical Center, Nashville, Tennessee 37232, USA.

Country: England

AGENCY: United States NIDDK

GRANT: R01 DK071052-01

ACRONYM: DK

MEDLINETA: J Mol Endocrinol

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