Molecular recognition of BMP-2 and BMP receptor IA.

Molecular recognition of BMP-2 and BMP receptor IA. Research Abstract Details 

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Molecular recognition of BMP-2 and BMP receptor IA. Abstract Text:

Sascha Keller,Joachim Nickel,Jin-Li Zhang,Walter Sebald,Thomas D Mueller,

Bone morphogenetic protein-2 (BMP-2) and other members of the TGF-beta superfamily regulate the development, maintenance and regeneration of tissues and organs. Binding epitopes for these extracellular signaling proteins have been defined, but hot spots specifying binding affinity and specificity have so far not been identified. In this study, mutational and structural analyses show that epitopes of BMP-2 and the BRIA receptor form a new type of protein-protein interface. The main chain atoms of Leu 51 and Asp53 of BMP-2 represent a hot spot of binding to BRIA. The BMP-2 variant L51P was deficient in type I receptor binding only, whereas its overall structure and its binding to type II receptors and modulator proteins, such as noggin, were unchanged. Thus, the L51P substitution converts BMP-2 into a receptor-inactive inhibitor of noggin. These results are relevant for other proteins of the TGF-beta superfamily and provide useful clues for structure-based drug design.

Molecular recognition of BMP-2 and BMP receptor IA. Publishing Authors By Initials

S Keller,J Nickel,JL Zhang,W Sebald,TD Mueller,

For similar peptides: intercellular signaling peptides and proteins: cytokines: transforming growth factor beta research abstracts see: peptides: intercellular signaling peptides and proteins: cytokines: transforming growth factor beta research

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Molecular recognition of BMP-2 and BMP receptor IA. Journal Published:

PUBLICATION TYPE: Research Support, Non-U.S. Gov

Journal: Nature structural & molecular biology

VOLUME: 11

Page Numbers: 481-8

Journal Abbreviation: Nat. Struct. Mol. Biol.

ISSN: 1545-9993

DAY: 4

MONTH: 04

YEAR: 2004

Molecular recognition of BMP-2 and BMP receptor IA. Information

Number of References:

LANGUAGE: eng

NlmUniqueID: 101186374

Molecular recognition of BMP-2 and BMP receptor IA. Keywords Mesh Terms:

KEYWORDS: Transforming Growth Factor beta

MESH TERMS: metabolism

Chemical & Substance for Abstract: Molecular recognition of BMP-2 and BMP receptor IA. Information

Substance Name: Protein-Serine-Threonine Kinases

Registry Number: EC 2.7.11.1

Grant and Affiliation Information for Molecular recognition of BMP-2 and BMP receptor IA.

AFFILIATION: Lehrstuhl für Physiologische Chemie II, Theodor-Boveri Institut für Biowissenschaften (Biozentrum), Universität Würzburg, Am Hubland, D-97074 Wuerzburg, Germany.

Country: United States

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MEDLINETA: Nat Struct Mol Biol

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