Molecular physiology and pharmacology of calcitonin.

Molecular physiology and pharmacology of calcitonin. Research Abstract Details 

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Molecular physiology and pharmacology of calcitonin. Abstract Text:

C L H Huang,L Sun,B S Moonga,M Zaidi,C L H Huang,L Sun,B S Moonga,M Zaidi,

Calcitonin is a thirty-two amino acid peptide that contains an N-terminal disulphide bridge and a C-terminal prolineamide residue. It is released from thyroid parafollicular C-cells and its direct actions on the osteoclast account for its physiological effects whether as a hypocalcaemic agent and a potent inhibitor of bone resorption. These effects likely reflect actions upon a number of specific osteoclast cell surface receptors that initiate intracellular signaling events through both cyclic AMP and calcium mediated second messenger pathways. Studies of its potent anti-resorptive effects have significant translational implications in the management of Paget's bone disease, osteoporosis, and hypercalcaemia. This chapter summarizes major concepts in the synthesis and structure of calcitonin and then proceeds to outline its cellular, molecular actions and therapeutic applications, whilst seeking to provide a reference source. More detailed accounts have been given on different aspects of calcitonin physiology and biochemistry in a number of recent reviews by ourselves and others (155,157, Zaidi et al., 1994; 2002).

Molecular physiology and pharmacology of calcitonin. Publishing Authors By Initials

CL Huang,L Sun,BS Moonga,M Zaidi,CL Huang,L Sun,BS Moonga,M Zaidi,

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Molecular physiology and pharmacology of calcitonin. Journal Published:

PUBLICATION TYPE: Research Support, U.S. Gov't,

Journal: Cellular and molecular biology (Noisy-le-Grand, Fr

VOLUME: 52

Page Numbers: 33-43

Journal Abbreviation: Cell. Mol. Biol. (Noisy-le-gra

ISSN: 1165-158X

DAY: 29

MONTH: 09

YEAR: 2006

Molecular physiology and pharmacology of calcitonin. Information

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LANGUAGE: eng

NlmUniqueID: 9216789

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Grant and Affiliation Information for Molecular physiology and pharmacology of calcitonin.

AFFILIATION: Physiological Laboratory, University of Cambridge, Cambridge, UK. clh11@cam.ac.uk

Country: France

AGENCY: United States NIA

GRANT: R01-AG14917-02

ACRONYM: AG

MEDLINETA: Cell Mol Biol (Noisy-le-grand)

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