Molecular pathogenesis of alpha-1-antitrypsin deficiency-associated liver disease: a meeting review.

Molecular pathogenesis of alpha-1-antitrypsin deficiency-associated liver disease: a meeting review. Research Abstract Details 

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Molecular pathogenesis of alpha-1-antitrypsin deficiency-associated liver disease: a meeting review. Abstract Text:

David H Perlmutter,Jeffrey L Brodsky,William F Balistreri,Bruce C Trapnell,

In recent years, we have witnessed several important paradigm shifts in understanding the molecular basis of liver disease in alpha-1-antitrypsin (AT) deficiency. These shifts have become possible as a result of a number of advances in research on the cell biology of aggregation-prone mutant proteins and in research on the pathobiological mechanisms of liver disease in general. Late-breaking research in these areas was the subject of an AASLD/Alpha-1 Foundation Single Topic Conference in Atlanta, Georgia, on January 26 to 28, 2006. The conference was titled "Alpha-1-Antitrypsin Deficiency and Other Liver Diseases Caused by Aggregated Proteins." Investigators from all over the world, representing a broad array of scientific disciplines and perspectives, discussed the pathobiology of AT deficiency, mechanisms of cell injury in diseases associated with aggregation-prone proteins, pathways by which cells respond to protein aggregation and mislocalization, and mechanisms of liver injury in general and in diseases related to AT deficiency. A session of the meeting was devoted to novel therapeutic strategies being developed for AT deficiency as well as to strategies either in development or already being applied to the class of diseases associated with mutant proteins.

Molecular pathogenesis of alpha-1-antitrypsin deficiency-associated liver disease: a meeting review. Publishing Authors By Initials

DH Perlmutter,JL Brodsky,WF Balistreri,BC Trapnell,

For similar skin and connective tissue diseases: connective tissue diseases: alpha 1-antitrypsin deficiency research abstracts see: skin and connective tissue diseases: connective tissue diseases: alpha 1-antitrypsin deficiency research

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Molecular pathogenesis of alpha-1-antitrypsin deficiency-associated liver disease: a meeting review. Journal Published:

PUBLICATION TYPE: Review

Journal: Hepatology (Baltimore, Md.)

VOLUME: 45

Page Numbers: 1313-23

Journal Abbreviation:

ISSN: 0270-9139

DAY: 3

MONTH: May

YEAR: 2007

Molecular pathogenesis of alpha-1-antitrypsin deficiency-associated liver disease: a meeting review. Information

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LANGUAGE: eng

NlmUniqueID: 8302946

Molecular pathogenesis of alpha-1-antitrypsin deficiency-associated liver disease: a meeting review. Keywords Mesh Terms:

KEYWORDS: alpha 1-Antitrypsin Deficiency

MESH TERMS: therapy

Chemical & Substance for Abstract: Molecular pathogenesis of alpha-1-antitrypsin deficiency-associated liver disease: a meeting review. Information

Substance Name: alpha 1-Antitrypsin

Registry Number: 0

Grant and Affiliation Information for Molecular pathogenesis of alpha-1-antitrypsin deficiency-associated liver disease: a meeting review.

AFFILIATION: Department of Pediatrics, University of Pittsburgh School of Medicine, Children's Hospital of Pittsburgh, Pittsburgh, PA 15213, USA. david.perlmutter@chp.edu

Country: United States

AGENCY: United States NIDDK

GRANT: 1 R13 DK075247-01

ACRONYM: DK

MEDLINETA: Hepatology

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