Molecular mimicry of human tumor antigen by heavy chain CDR3 sequence of the anti-idiotypic antibody.

Molecular mimicry of human tumor antigen by heavy chain CDR3 sequence of the anti-idiotypic antibody. Research Abstract Details 

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Molecular mimicry of human tumor antigen by heavy chain CDR3 sequence of the anti-idiotypic antibody. Abstract Text:

D Luo,W Qi,J Ma,Y J Wang,D Wishart,

We isolated and characterized an anti-idiotype monoclonal antibody (AR42.1) which is capable of mimicking a distinct and specific epitope of MUC-1 antigen. The cDNA sequences coding for the AR42.1 variable regions were determined. We found significant amino acid homology between complementary determining regions 3 (CDR3) in the heavy chain of AR42.1 and the determinant epitope sequence of MUC-1. This 10 amino acid sequence may represent an "internal image" of the anti-idiotype antibody to the MUC-1 antigen, and could be used for development of a MUC-1 surrogate for immunotherapy.

Molecular mimicry of human tumor antigen by heavy chain CDR3 sequence of the anti-idiotypic antibody. Publishing Authors By Initials

D Luo,W Qi,J Ma,YJ Wang,D Wishart,

For similar biochemical phenomena, metabolism, and nutrition: biochemical phenomena: sequence homology: sequence homology, amino acid research abstracts see: biochemical phenomena, metabolism, and nutrition: biochemical phenomena: sequence homology: sequence homology, amino acid research

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Molecular mimicry of human tumor antigen by heavy chain CDR3 sequence of the anti-idiotypic antibody. Journal Published:

PUBLICATION TYPE: Journal Article

Journal: Journal of biochemistry

VOLUME: 128

Page Numbers: 345-7

Journal Abbreviation: J. Biochem.

ISSN: 0021-924X

DAY: 19

MONTH: Sep

YEAR: 2000

Molecular mimicry of human tumor antigen by heavy chain CDR3 sequence of the anti-idiotypic antibody. Information

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LANGUAGE: eng

NlmUniqueID: 376600

Molecular mimicry of human tumor antigen by heavy chain CDR3 sequence of the anti-idiotypic antibody. Keywords Mesh Terms:

KEYWORDS: Sequence Homology, Amino Acid

MESH TERMS: immunology

Chemical & Substance for Abstract: Molecular mimicry of human tumor antigen by heavy chain CDR3 sequence of the anti-idiotypic antibody. Information

Substance Name: Immunoglobulin Heavy Chains

Registry Number: 0

Grant and Affiliation Information for Molecular mimicry of human tumor antigen by heavy chain CDR3 sequence of the anti-idiotypic antibody.

AFFILIATION: AltaRex Corp., 1131 Dentistry-Pharmacy, Alberta, Canada. dluo@u.washington.edu

Country: JAPAN

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MEDLINETA: J Biochem

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