Molecular mechanisms of resistance and toxicity associated with platinating agents.

Molecular mechanisms of resistance and toxicity associated with platinating agents. Research Abstract Details 

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Molecular mechanisms of resistance and toxicity associated with platinating agents. Abstract Text:

Cara A Rabik,M Eileen Dolan,

Platinating agents, including cisplatin, carboplatin, and oxaliplatin, have been used clinically for nearly 30years as part of the treatment of many types of cancers, including head and neck, testicular, ovarian, cervical, lung, colorectal and relapsed lymphoma. The cytotoxic lesion of platinating agents is thought to be the platinum intrastrand crosslink that forms on DNA, although treatment activates a number of signal transduction pathways. Treatment with these agents is characterized by resistance, both acquired and intrinsic. This resistance can be caused by a number of cellular adaptations, including reduced uptake, inactivation by glutathione and other anti-oxidants, and increased levels of DNA repair or DNA tolerance. Here we investigate the pathways that treatment with platinating agents activate, the mechanisms of resistance, potential candidate genes involved in the development of resistance, and associated clinical toxicities. Although the purpose of this review is to provide an overview of cisplatin, carboplatin, and oxaliplatin, we have focused primarily on preclinical data that has clinical relevance generated over the past five years.

Molecular mechanisms of resistance and toxicity associated with platinating agents. Publishing Authors By Initials

CA Rabik,ME Dolan,

For similar biological phenomena, cell phenomena, and immunity: cell physiology: cell communication: signal transduction research abstracts see: biological phenomena, cell phenomena, and immunity: cell physiology: cell communication: signal transduction research

PUBMED ID PMID:

MEDLINE DATE:

Molecular mechanisms of resistance and toxicity associated with platinating agents. Journal Published:

PUBLICATION TYPE: Review

Journal: Cancer treatment reviews

VOLUME: 33

Page Numbers: 9-23

Journal Abbreviation: Cancer Treat. Rev.

ISSN: 0305-7372

DAY: 3

MONTH: 11

YEAR: 2006

Molecular mechanisms of resistance and toxicity associated with platinating agents. Information

Number of References: 169

LANGUAGE: eng

NlmUniqueID: 7502030

Molecular mechanisms of resistance and toxicity associated with platinating agents. Keywords Mesh Terms:

KEYWORDS: Signal Transduction

MESH TERMS: drug effects

Chemical & Substance for Abstract: Molecular mechanisms of resistance and toxicity associated with platinating agents. Information

Substance Name: oxaliplatin

Registry Number: 63121-00-6

Grant and Affiliation Information for Molecular mechanisms of resistance and toxicity associated with platinating agents.

AFFILIATION: Department of Medicine, Committee on Clinical Pharmacology and Pharmacogenomics, University of Chicago, 5841 S. Maryland Avenue, Box MC2115, Section of Hem-Onc, Chicago, IL 60637, United States.

Country: England

AGENCY: United States NCI

GRANT: R01 CA081485-07

ACRONYM: CA

MEDLINETA: Cancer Treat Rev

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