Molecular mechanisms of GD3-induced apoptosis in U-1242 MG glioma cells.

Molecular mechanisms of GD3-induced apoptosis in U-1242 MG glioma cells. Research Abstract Details 

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Molecular mechanisms of GD3-induced apoptosis in U-1242 MG glioma cells. Abstract Text:

O M Omran,H E Saqr,Allan J Yates,

An increasing amount of evidence indicates that the disialoganglioside GD3 is involved in apoptosis in many cell lines. Our previous studies demonstrated that endogenous GD3 expression induced apoptosis in U-1242 MG glioma cells transfected with the GD3 synthase gene (U1242MG-GD3 cells). In this paper, we present further investigations on the molecular mechanisms of GD3-induced apoptosis in this cell line. We found that endogenously synthesized GD3 localizes to the caveolae of this cell line, where it promotes the localization of death receptor 5 (DR5), tumor necrosis factor receptor-1 (TNF-R1), and Fas (Apo-1) to the caveolae. In addition, caspase-8 was translocated to the caveolar fraction and cleaved; the cleaved proteins were then re-located into the high density fractions. However, GD3 had no effect on the distribution of the adapter protein Fas-associated death domain (FADD). We conclude that GD3 functions as a regulatory molecule early in the extrinsic apoptosis pathway.

Molecular mechanisms of GD3-induced apoptosis in U-1242 MG glioma cells. Publishing Authors By Initials

OM Omran,HE Saqr,AJ Yates,

For similar animals: chordata: vertebrates: mammals: primates: haplorhini: catarrhini: hominidae: humans research abstracts see: animals: chordata: vertebrates: mammals: primates: haplorhini: catarrhini: hominidae: humans research

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Molecular mechanisms of GD3-induced apoptosis in U-1242 MG glioma cells. Journal Published:

PUBLICATION TYPE: Research Support, Non-U.S. Gov

Journal: Neurochemical research

VOLUME: 31

Page Numbers: 1171-80

Journal Abbreviation: Neurochem. Res.

ISSN: 0364-3190

DAY: 17

MONTH: 10

YEAR: 2006

Molecular mechanisms of GD3-induced apoptosis in U-1242 MG glioma cells. Information

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LANGUAGE: eng

NlmUniqueID: 7613461

Molecular mechanisms of GD3-induced apoptosis in U-1242 MG glioma cells. Keywords Mesh Terms:

KEYWORDS: Humans

MESH TERMS: pathology

Chemical & Substance for Abstract: Molecular mechanisms of GD3-induced apoptosis in U-1242 MG glioma cells. Information

Substance Name: Caspase 8

Registry Number: EC 3.4.22.-

Grant and Affiliation Information for Molecular mechanisms of GD3-induced apoptosis in U-1242 MG glioma cells.

AFFILIATION: Department of Pathology, The Ohio State University, 4170 Graves Hall, 333 W 10Th Ave, Columbus, OH 43210, USA.

Country: United States

AGENCY: United States NCI

GRANT: CA85799

ACRONYM: CA

MEDLINETA: Neurochem Res

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