Molecular mechanisms of astrogliosis: new approaches with mouse genetics.

Molecular mechanisms of astrogliosis: new approaches with mouse genetics. Research Abstract Details 

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Molecular mechanisms of astrogliosis: new approaches with mouse genetics. Abstract Text:

Lina S Correa-Cerro,James W Mandell,

Astrocytes are increasingly being recognized as dynamic participants in many aspects of normal central nervous system function. In disease states, reactive astrocytes undergo complex phenotypic changes, generically referred to as astrogliosis. Unraveling the functions of reactive astrocytes and underlying molecular mechanisms is a difficult problem. The use of genetically modified mice is beginning to yield some answers to long-standing questions in the field. What are the functions of reactive astrocytes? What extracellular factors and intracellular signaling mechanisms are responsible for astrocyte activation in various forms of neural injury? In this review we will highlight studies using astrocyte reporter lines for cellular imaging and lineage tracing, as well as gain- and loss-of-function mutations that have begun to shed light on mechanisms of astrogliosis.

Molecular mechanisms of astrogliosis: new approaches with mouse genetics. Publishing Authors By Initials

LS Correa-Cerro,JW Mandell,

For similar nervous system: neuroglia research abstracts see: nervous system: neuroglia research

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Molecular mechanisms of astrogliosis: new approaches with mouse genetics. Journal Published:

PUBLICATION TYPE: Review

Journal: Journal of neuropathology and experimental neurolo

VOLUME: 66

Page Numbers: 169-76

Journal Abbreviation: J. Neuropathol. Exp. Neurol.

ISSN: 0022-3069

DAY: 3

MONTH: Mar

YEAR: 2007

Molecular mechanisms of astrogliosis: new approaches with mouse genetics. Information

Number of References: 54

LANGUAGE: eng

NlmUniqueID: 2985192

Molecular mechanisms of astrogliosis: new approaches with mouse genetics. Keywords Mesh Terms:

KEYWORDS: Neuroglia

MESH TERMS: pathology

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Grant and Affiliation Information for Molecular mechanisms of astrogliosis: new approaches with mouse genetics.

AFFILIATION: Department of Pathology, Division of Neuropathology, University of Virginia School of Medicine, Charlottesville, Virginia, USA.

Country: United States

AGENCY: United States NINDS

GRANT: NS047378

ACRONYM: NS

MEDLINETA: J Neuropathol Exp Neurol

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