Molecular mechanism of regulation of the calcium-binding protein calbindin-D(9k), and its physiological role(s) in mammals: a review of current research.

Molecular mechanism of regulation of the calcium-binding protein calbindin-D(9k), and its physiological role(s) in mammals: a review of current research. Research Abstract Details 

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Molecular mechanism of regulation of the calcium-binding protein calbindin-D(9k), and its physiological role(s) in mammals: a review of current research. Abstract Text:

Calbindin-D(9k) (CaBP-9k) is a cytosolic calcium-binding protein that is expressed in a variety of tissues, such as uterus, placenta, intestine, kidney, pituitary gland and bone. At present, the precise role(s) of CaBP-9k remains to be clarified. CaBP-9k-null mice are normal, which indicates that other calcium-transporter genes can compensate for the lack CaBP-9k. Uterine CaBP-9k has been shown to be involved in the regulation of myometrial activity by intracellular calcium. In the uterus and placenta, CaBP-9k expression is regulated by the sex steroid hormones oestrogen (E2) and progesterone (P4). Intestinal CaBP-9k is involved in intestinal calcium absorption, and is regulated at the transcriptional and post-transcriptional levels by 1,25-dihydroxyvitamin D3, the hormonal form of vitamin D. Thus, evidence to date suggests that CaBP-9k may be regulated in a tissue-specific manner. In this review, we will summarize current data on the molecular mechanism of regulation of CaBP-9k in mammals, including recent research data generated in our laboratories.

Molecular mechanism of regulation of the calcium-binding protein calbindin-D(9k), and its physiological role(s) in mammals: a review of current research. Publishing Authors By Initials

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MEDLINE DATE: 2008 Mar-Apr

Molecular mechanism of regulation of the calcium-binding protein calbindin-D(9k), and its physiological role(s) in mammals: a review of current research. Journal Published:

PUBLICATION TYPE: Journal Article

Journal: Journal of cellular and molecular medicine

VOLUME: 12

Page Numbers: 409-20

Journal Abbreviation: J. Cell. Mol. Med.

ISSN: 1582-1838

DAY: 20

MONTH: 12

YEAR: 2007

Molecular mechanism of regulation of the calcium-binding protein calbindin-D(9k), and its physiological role(s) in mammals: a review of current research. Information

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LANGUAGE: eng

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Grant and Affiliation Information for Molecular mechanism of regulation of the calcium-binding protein calbindin-D(9k), and its physiological role(s) in mammals: a review of current research.

AFFILIATION: Department of Obstetrics and Gynecology, Faculty of Medicine, Child and Family Research Institute, University of British Columbia, Vancouver, Canada.

Country: Romania

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MEDLINETA: J Cell Mol Med

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