Molecular mechanism of immune response induced by foreign plasmid DNA after oral administration in mice.

Molecular mechanism of immune response induced by foreign plasmid DNA after oral administration in mice. Research Abstract Details 

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Molecular mechanism of immune response induced by foreign plasmid DNA after oral administration in mice. Abstract Text:

Jian-Wen Liu,Jun Cheng,

AIM: To study immune response induced by foreign plasmid DNA after oral administration in mice. METHODS: Mice were orally administered with 200 mug of plasmid pcDNA3 once and spleen was isolated 4 h and 18 h after administration. Total RNA was extracted from spleen and gene expression profile of BALB/c mice spleen was analyzed by using Affymetrix oligonucleotide GeneChip. Functional cluster analysis was conducted by GenMAPP software. RESULTS: At 4 h and 18 h after oral plasmid pcDNA3 administration, a number of immune-related genes, including cytokine and cytokine receptors, chemokines and chemokine receptor, complement molecule, proteasome, histocompatibility molecule, lymphocyte antigen complex and apoptotic genes, were up-regulated. Moreover, MAPPFinder results also showed that numerous immune response processes were up-regulated. In contrast, the immunoglobulin genes were down-regulated. CONCLUSION: Foreign plasmid DNA can modulate the genes expression related to immune system via the gastrointestinal tract, and further analysis of the related immune process may help understand the molecular mechanisms of immune response induced by foreign plasmid via the gastrointestinal tract.

Molecular mechanism of immune response induced by foreign plasmid DNA after oral administration in mice. Publishing Authors By Initials

JW Liu,J Cheng,

For similar tissues: lymphoid tissue: spleen research abstracts see: tissues: lymphoid tissue: spleen research

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Molecular mechanism of immune response induced by foreign plasmid DNA after oral administration in mice. Journal Published:

PUBLICATION TYPE: Research Support, Non-U.S. Gov

Journal: World journal of gastroenterology : WJG

VOLUME: 13

Page Numbers: 3847-54

Journal Abbreviation: World J. Gastroenterol.

ISSN: 1007-9327

DAY: 28

MONTH: Jul

YEAR: 2007

Molecular mechanism of immune response induced by foreign plasmid DNA after oral administration in mice. Information

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LANGUAGE: eng

NlmUniqueID: 100883448

Molecular mechanism of immune response induced by foreign plasmid DNA after oral administration in mice. Keywords Mesh Terms:

KEYWORDS: Spleen

MESH TERMS: metabolism

Chemical & Substance for Abstract: Molecular mechanism of immune response induced by foreign plasmid DNA after oral administration in mice. Information

Substance Name: DNA, Circular

Registry Number: 0

Grant and Affiliation Information for Molecular mechanism of immune response induced by foreign plasmid DNA after oral administration in mice.

AFFILIATION: Institute of Infectious Diseases, Beijing Ditan Hospital, Beijing 100011, China. ljw_ftpt@yahoo.com.cn

Country: China

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MEDLINETA: World J Gastroenterol

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