Molecular mechanism of bovine trabecular meshwork cells apoptosis induced by dexamethasone and protection by pilocarpine.

Molecular mechanism of bovine trabecular meshwork cells apoptosis induced by dexamethasone and protection by pilocarpine. Research Abstract Details 

Research Abstract Table of Contents

Jump to the:

Molecular mechanism of bovine trabecular meshwork cells apoptosis induced by dexamethasone and protection by pilocarpine. Abstract Text:

Yajuan Gu,Shujun Zeng,Pengxin Qiu,Yuping Wu,Dawei Peng,Guangmei Yan,

PURPOSE: To study the molecular mechanism of trabecular meshwork cells apoptosis induced by dexamethasone and the protection of pilocarpine. METHODS: Determining mRNA expression with reverse transcription-polymerase chain protein expression with Western blots and the percentage of reaction (RT-PCR), apoptotic cells with fluorescent microscopy. RESULTS: Dexamethasone up-regulated Fas proteins and affected Bax, caspase-8 and caspase-9 proteins in an action of first decrease then increase. Pre -treatment with pilocarpine decreased the four proteins expression, which were increased by dexamethasone. Pilocarpine self could decrease pro-apoptotic factors Bax, caspase-8 and caspase-9 proteins expression. CONCLUSION: Fas/FasL pathway participated in apoptotic process induced by dexamethasone in trabecular meshwork cells and the process was probably related with both caspase-8 and caspase-9 pathways. Pilocarpine protected the cells against apoptosis through down-regulating Fas, Bax, caspase-8 and caspase-9 proteins expression.

Molecular mechanism of bovine trabecular meshwork cells apoptosis induced by dexamethasone and protection by pilocarpine. Publishing Authors By Initials

Y Gu,S Zeng,P Qiu,Y Wu,D Peng,G Yan,

For similar abstracts research abstracts see: abstracts research

PUBMED ID PMID:

MEDLINE DATE:

Molecular mechanism of bovine trabecular meshwork cells apoptosis induced by dexamethasone and protection by pilocarpine. Journal Published:

PUBLICATION TYPE: Research Support, Non-U.S. Gov

Journal: Yan ke xue bao = Eye science / "Yan ke xue bao" bi

VOLUME: 21

Page Numbers: 44-51, 61

Journal Abbreviation:

ISSN: 1000-4432

DAY: 13

MONTH: Mar

YEAR: 2005

Molecular mechanism of bovine trabecular meshwork cells apoptosis induced by dexamethasone and protection by pilocarpine. Information

Number of References:

LANGUAGE: eng

NlmUniqueID: 8605666

Molecular mechanism of bovine trabecular meshwork cells apoptosis induced by dexamethasone and protection by pilocarpine. Keywords Mesh Terms:

KEYWORDS:

MESH TERMS:

Chemical & Substance for Abstract: Molecular mechanism of bovine trabecular meshwork cells apoptosis induced by dexamethasone and protection by pilocarpine. Information

Substance Name:

Registry Number:

Grant and Affiliation Information for Molecular mechanism of bovine trabecular meshwork cells apoptosis induced by dexamethasone and protection by pilocarpine.

AFFILIATION: Department of Pharmacology, Zhongshan Medical School, Sun Yat-sen University, Guangzhou 510089, China.

Country: China

AGENCY:

GRANT:

ACRONYM:

MEDLINETA: Yan Ke Xue Bao

REFSOURCE:

DATABASENAME:

ACCESSION NUMBER:

Number Hits: 0

Molecular mechanism of bovine trabecular meshwork cells apoptosis induced by dexamethasone and protection by pilocarpine Related Publications

• Dietary vitamin E protects the fathead minnow, Pimephales promelas, against noise exposure.
• Processing and cryopreservation for 1963 units of human umbilical cord blood.
• [A basic research to share Fourier transform near-infrared spectrum information resource]
• [A rapid and high throughput method for apoE genotyping]
• [Analysis of resveratrol by pressurized-capillary electrochromatography]
• [C721T mutation of the alpha 1,3 galactosyltransferase gene responsible for Bw subgroup]
• [CALM-AF10 fusion transcripts in primary leukemia with t(10;11) and in vitro chemotherapy sensitivity of leukemic cells with t(10;11)]
• [Cloning of the NS1 gene of dengue-2 virus and determination of its partial nucleotide sequence]
• [Comparative experimental study on treatment of rat's injured sciatic nerve with electroacupuncture and Buyang Huanwu Decoction]
• [Comparison of autologous and allogeneic hematopoietic stem cell transplantation for 140 patients with de novo acute leukemia in first complete remission]
• [Determination of trace rare earth in fossil of dinosaurian egg by laser thermal lens spectrometry]
• [Determinations of indole and methylindole in air by gas chromatography]
• [Effect of soluble anti-CD47 monoclonal antibody on the differentiation and function of human dendritic cells.]
• [Function of eukaryotic transcription factor NF-kappaB in the signal transduction of acute inflammatory response]
• [Influence of FT-NIR spectrometer scanning requirements on the math model's precision]
• [Method of heart rate variability analysis and its application in the field of space medicine]
• [Polymorphisms of six short tandem repeat loci in Zhejiang She ethnic population and Zhejiang Hans of China]
• [Preparation, identification and application of anti-P450scc antibody]
• [Progress on the researches of karyotypes of Chinese spiders]
• [Proliferating cell nuclear antigen expression in recurrent aphthous ulcer and its significance]
• [Rapid manufacturing of degradable porous polymer bone scaffold]
• [Review on job burnout.]
• [Significance of microvascular density and vascular endothelial growth factor in breast cancer]
• [Studies on PANK2 gene mutations in Chinese patients with Hallervorden-Spatz syndrome]
• [Studies on expansion ex vivo of murine bone marrow cells and its hematopoietic reconstitution capacity]
• [Study on the hypotensive effect of manascus]
• [Study on viscosity property of gastrointestinal mucus]
• [The crude drugs of special location of Sichuan as viewed from the tribute drugs in the Tang dynasty]
• [The survey of HIV prevalence among children between 0 to 7 years old in one county in China]
• [The synthesis and absorption spectrum of [Fe(C60)] x ClO]