Molecular Markers and Changes of Computed Tomography Appearance in Lung Adenocarcinoma with Ground-glass Opacity.

Molecular Markers and Changes of Computed Tomography Appearance in Lung Adenocarcinoma with Ground-glass Opacity. Research Abstract Details 

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Molecular Markers and Changes of Computed Tomography Appearance in Lung Adenocarcinoma with Ground-glass Opacity. Abstract Text:

Yukihiro Yoshida,Akiko Kokubu,Kenji Suzuki,Hidehiko Kuribayashi,Koji Tsuta,Yoshihiro Matsuno,Masahiko Kusumoto,Yae Kanai,Hisao Asamura,Setsuo Hirohashi,Tatsuhiro Shibata,Yukihiro Yoshida,Akiko Kokubu,Kenji Suzuki,Hidehiko Kuribayashi,Koji Tsuta,Yoshihiro Matsuno,Masahiko Kusumoto,Yae Kanai,Hisao Asamura,Setsuo Hirohashi,Tatsuhiro Shibata,Yukihiro Yoshida,Akiko Kokubu,Kenji Suzuki,Hidehiko Kuribayashi,Koji Tsuta,Yoshihiro Matsuno,Masahiko Kusumoto,Yae Kanai,Hisao Asamura,Setsuo Hirohashi,Tatsuhiro Shibata,

BACKGROUND: High-resolution computed tomography (HRCT) of lung adenocarcinoma at early stage shows pure ground-glass opacity (GGO) and most cases of pure GGO remain stable during follow-up. There is no consensus on the strategy for follow-up. Identification of the molecular mechanisms that are associated with the natural history of lung adenocarcinoma should provide useful information. METHODS: Twenty-three lung adenocarcinomas that were followed-up for more than 6 months pre-operatively by HRCT were included in this study. Patterns of radiological changes during the follow-up period were classified into three groups; type 1, pure GGO without consolidation; type 2, appearance or increase in consolidation within pure GGO; type 3, consolidation without pure GGO. Mutational analysis of the epidermal growth factor receptor (EGFR) and K-ras genes and immunohistochemical staining of p53 protein were performed. RESULTS: EGFR mutations were found in 17 cases (74%), and there was no K-ras mutation. Positive staining of p53 was found in 8 cases (35%). As for radiological findings during the follow-up period, the frequencies of EGFR mutations and positive p53 staining were 67 and 0% in type 1 (n = 9), 89 and 44% in type 2 (n = 9) and 60 and 80% in type 3 (n = 5). CONCLUSIONS: EGFR mutations were frequently found in lung adenocarcinoma with GGO on HRCT in this study. Inactivation of p53 may be associated with the appearance of central consolidation within pure GGO on HRCT which reflects invasive features and may be useful as a molecular marker during the follow-up of pure GGO.

Molecular Markers and Changes of Computed Tomography Appearance in Lung Adenocarcinoma with Ground-glass Opacity. Publishing Authors By Initials

Y Yoshida,A Kokubu,K Suzuki,H Kuribayashi,K Tsuta,Y Matsuno,M Kusumoto,Y Kanai,H Asamura,S Hirohashi,T Shibata,Y Yoshida,A Kokubu,K Suzuki,H Kuribayashi,K Tsuta,Y Matsuno,M Kusumoto,Y Kanai,H Asamura,S Hirohashi,T Shibata,Y Yoshida,A Kokubu,K Suzuki,H Kuribayashi,K Tsuta,Y Matsuno,M Kusumoto,Y Kanai,H Asamura,S Hirohashi,T Shibata,

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Molecular Markers and Changes of Computed Tomography Appearance in Lung Adenocarcinoma with Ground-glass Opacity. Journal Published:

PUBLICATION TYPE: Journal Article

Journal: Japanese journal of clinical oncology

VOLUME: 37

Page Numbers: 907-12

Journal Abbreviation: Jpn. J. Clin. Oncol.

ISSN: 1465-3621

DAY: 18

MONTH: 12

YEAR: 2007

Molecular Markers and Changes of Computed Tomography Appearance in Lung Adenocarcinoma with Ground-glass Opacity. Information

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LANGUAGE: eng

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AFFILIATION: Cancer Genomics Project, National Cancer Center Research Institute, 5-1-1, Tsukiji, Chuo-ku, Tokyo 104-0045, Japan. tashibat@ncc.go.jp.

Country: Japan

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MEDLINETA: Jpn J Clin Oncol

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