Molecular inversion probe analysis of gene copy alterations reveals distinct categories of colorectal carcinoma.

Molecular inversion probe analysis of gene copy alterations reveals distinct categories of colorectal carcinoma. Research Abstract Details 

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Molecular inversion probe analysis of gene copy alterations reveals distinct categories of colorectal carcinoma. Abstract Text:

Hanlee Ji,Jochen Kumm,Michael Zhang,Kyle Farnam,Keyan Salari,Malek Faham,James M Ford,Ronald W Davis,

Genomic instability is a major feature of neoplastic development in colorectal carcinoma and other cancers. Specific genomic instability events, such as deletions in chromosomes and other alterations in gene copy number, have potential utility as biologically relevant prognostic biomarkers. For example, genomic deletions on chromosome arm 18q are an indicator of colorectal carcinoma behavior and potentially useful as a prognostic indicator. Adapting a novel genomic technology called molecular inversion probes which can determine gene copy alterations, such as genomic deletions, we designed a set of probes to interrogate several hundred individual exons of >200 cancer genes with an overall distribution covering all chromosome arms. In addition, >100 probes were designed in close proximity of microsatellite markers on chromosome arm 18q. We analyzed a set of colorectal carcinoma cell lines and primary colorectal tumor samples for gene copy alterations and deletion mutations in exons. Based on clustering analysis, we distinguished the different categories of genomic instability among the colorectal cancer cell lines. Our analysis of primary tumors uncovered several distinct categories of colorectal carcinoma, each with specific patterns of 18q deletions and deletion mutations in specific genes. This finding has potential clinical ramifications given the application of 18q loss of heterozygosity events as a potential indicator for adjuvant treatment in stage II colorectal carcinoma.

Molecular inversion probe analysis of gene copy alterations reveals distinct categories of colorectal carcinoma. Publishing Authors By Initials

H Ji,J Kumm,M Zhang,K Farnam,K Salari,M Faham,JM Ford,RW Davis,

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Molecular inversion probe analysis of gene copy alterations reveals distinct categories of colorectal carcinoma. Journal Published:

PUBLICATION TYPE: Research Support, N.I.H., Extr

Journal: Cancer research

VOLUME: 66

Page Numbers: 7910-9

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ISSN: 1538-7445

DAY: 15

MONTH: Aug

YEAR: 2006

Molecular inversion probe analysis of gene copy alterations reveals distinct categories of colorectal carcinoma. Information

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LANGUAGE: eng

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Grant and Affiliation Information for Molecular inversion probe analysis of gene copy alterations reveals distinct categories of colorectal carcinoma.

AFFILIATION: Division of Oncology, Department of Medicine, Stanford University School of Medicine, Stanford, CA 94305-5151, USA. hanleeji@stanford.edu

Country: United States

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MEDLINETA: Cancer Res

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