Molecular immune responses of the mosquito Anopheles gambiae to bacteria and malaria parasites.

Molecular immune responses of the mosquito Anopheles gambiae to bacteria and malaria parasites. Research Abstract Details 

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Molecular immune responses of the mosquito Anopheles gambiae to bacteria and malaria parasites. Abstract Text:

Immune responses of the malaria vector mosquito Anopheles gambiae were monitored systematically by the induced expression of five RNA markers after infection challenge. One newly isolated marker encodes a homologue of the moth Gram-negative bacteria-binding protein (GNBP), and another corresponds to a serine protease-like molecule. Additional previously described markers that respond to immune challenge encode the antimicrobial peptide defensin, a putative galactose lectin, and a putative serine protease. Specificity of the immune responses was indicated by differing temporal patterns of induction of specific markers in bacteria-challenged larvae and adults, and by variations in the effectiveness of different microorganisms and their components for marker induction in an immune-responsive cell line. The markers exhibit spatially distinct patterns of expression in the adult female mosquito. Two of them are highly expressed in different regions of the midgut, one in the anterior and the other in the posterior midgut. Marker induction indicates a significant role of the midgut in insect innate immunity. Immune responses to the penetration of the midgut epithelium by a malaria parasite occur both within the midgut itself and elsewhere in the body, suggesting an immune-related signaling process.

Molecular immune responses of the mosquito Anopheles gambiae to bacteria and malaria parasites. Publishing Authors By Initials

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Molecular immune responses of the mosquito Anopheles gambiae to bacteria and malaria parasites. Journal Published:

PUBLICATION TYPE: Research Support, Non-U.S. Gov

Journal: Proceedings of the National Academy of Sciences of

VOLUME: 94

Page Numbers: 11508-13

Journal Abbreviation: Proc. Natl. Acad. Sci. U.S.A.

ISSN: 0027-8424

DAY: 14

MONTH: Oct

YEAR: 1997

Molecular immune responses of the mosquito Anopheles gambiae to bacteria and malaria parasites. Information

Number of References:

LANGUAGE: eng

NlmUniqueID: 7505876

Molecular immune responses of the mosquito Anopheles gambiae to bacteria and malaria parasites. Keywords Mesh Terms:

KEYWORDS: Sequence Homology, Amino Acid

MESH TERMS: immunology

Chemical & Substance for Abstract: Molecular immune responses of the mosquito Anopheles gambiae to bacteria and malaria parasites. Information

Substance Name: Insect Proteins

Registry Number: 0

Grant and Affiliation Information for Molecular immune responses of the mosquito Anopheles gambiae to bacteria and malaria parasites.

AFFILIATION: European Molecular Biology Laboratory, Meyerhofstrasse 1, 69117 Heidelberg, Germany.

Country: UNITED STATES

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MEDLINETA: Proc Natl Acad Sci U S A

REFSOURCE: Proc Natl Acad Sci U S A. 1997 Oct 14;94

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ACCESSION NUMBER: AJ001042

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