Molecular evolution of hemojuvelin and the repulsive guidance molecule family.

Molecular evolution of hemojuvelin and the repulsive guidance molecule family. Research Abstract Details 

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Molecular evolution of hemojuvelin and the repulsive guidance molecule family. Abstract Text:

Laura Marie Camus,Lisa A Lambert,

Repulsive guidance molecules (RGMs) are found in vertebrates and chordates and are involved in embryonic development and iron homeostasis. Members of this family are GPI-linked membrane proteins that contain an N-terminal signal peptide, a C-terminal propeptide, and a conserved RGD motif. Vertebrates are known to possess three paralogues; RGMA and RGMB (sometimes called Dragon) are expressed in the nervous system and are thought to play various roles in neural development. Hemojuvelin (HJV; also called repulsive guidance molecule c, RGMC) is the third member of this family, and mutations in this gene result in a form of juvenile hemochromatosis (type 2A). Phylogenetic analyses of 55 different RGM family sequences from 21 different species support the existence of a novel gene, found only in fish, which we have labeled RGMD. The pattern of conserved residues in each family identifies new candidates for important functional roles, including ligand binding.

Molecular evolution of hemojuvelin and the repulsive guidance molecule family. Publishing Authors By Initials

LM Camus,LA Lambert,

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Molecular evolution of hemojuvelin and the repulsive guidance molecule family. Journal Published:

PUBLICATION TYPE: Journal Article

Journal: Journal of molecular evolution

VOLUME: 65

Page Numbers: 68-81

Journal Abbreviation: J. Mol. Evol.

ISSN: 0022-2844

DAY: 25

MONTH: 06

YEAR: 2007

Molecular evolution of hemojuvelin and the repulsive guidance molecule family. Information

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LANGUAGE: eng

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Grant and Affiliation Information for Molecular evolution of hemojuvelin and the repulsive guidance molecule family.

AFFILIATION: Department of Biology, Chatham University, Woodland Road, Pittsburgh, PA 15232, USA.

Country: Germany

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MEDLINETA: J Mol Evol

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