Molecular evidence for the ancient origin of the ribosomal protection protein that mediates tetracycline resistance in bacteria.

Molecular evidence for the ancient origin of the ribosomal protection protein that mediates tetracycline resistance in bacteria. Research Abstract Details 

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Molecular evidence for the ancient origin of the ribosomal protection protein that mediates tetracycline resistance in bacteria. Abstract Text:

Takeshi Kobayashi,Lisa Nonaka,Fumito Maruyama,Satoru Suzuki,Takeshi Kobayashi,Lisa Nonaka,Fumito Maruyama,Satoru Suzuki,Takeshi Kobayashi,Lisa Nonaka,Fumito Maruyama,Satoru Suzuki,

The ribosomal protection proteins (RPPs) mediate the resistance to tetracycline (TC) in Gram-positive and Gram-negative bacteria. The RPPs display sequence similarity to translation elongation factors, EF-G/EF-2 and EF-Tu/EF-1alpha. To determine the evolutionary origin of the RPPs, we constructed a composite phylogenetic tree of the RPPs, EF-G/EF-2 and EF-Tu/EF-1alpha. This tree includes two universal trees for the EF-G/EF-2 and EF-Tu/EF-1alpha, which form clusters corresponding to the respective two groups of proteins from three superkingdoms. The cluster of RPPs was placed at a point between the EF-G/EF-2 and EF-Tu/EF-1alpha clusters. The branch length (substitutions/site) between the node for the RPP cluster and the primary divergence of the RPPs was statistically shorter than that between the node for this cluster and the primary divergence in the EF-G/EF-2 cluster. This indicates that the RPPs derived through duplication and divergence of the ancient GTPase before the divergence of the three superkingdoms. Furthermore, this suggests the RPPs' extant function occurred before the streptomycetes that include the TC-producing strains. Therefore, the RPPs evolved independent of the presence of TCs and serve a function other than antibiotic resistance. The RPPs may provide ribosomal protection against other chemical substances in the environment.

Molecular evidence for the ancient origin of the ribosomal protection protein that mediates tetracycline resistance in bacteria. Publishing Authors By Initials

T Kobayashi,L Nonaka,F Maruyama,S Suzuki,T Kobayashi,L Nonaka,F Maruyama,S Suzuki,T Kobayashi,L Nonaka,F Maruyama,S Suzuki,

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Molecular evidence for the ancient origin of the ribosomal protection protein that mediates tetracycline resistance in bacteria. Journal Published:

PUBLICATION TYPE: Research Support, Non-U.S. Gov

Journal: Journal of molecular evolution

VOLUME: 65

Page Numbers: 228-35

Journal Abbreviation: J. Mol. Evol.

ISSN: 0022-2844

DAY: 4

MONTH: 08

YEAR: 2007

Molecular evidence for the ancient origin of the ribosomal protection protein that mediates tetracycline resistance in bacteria. Information

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LANGUAGE: eng

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Grant and Affiliation Information for Molecular evidence for the ancient origin of the ribosomal protection protein that mediates tetracycline resistance in bacteria.

AFFILIATION: Center for Marine Environmental Studies (CMES), Ehime University, Matsuyama, Ehime, Japan.

Country: Germany

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MEDLINETA: J Mol Evol

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