Molecular epidemiology of enterovirus 71 infection in the Western Pacific Region.

Molecular epidemiology of enterovirus 71 infection in the Western Pacific Region. Research Abstract Details 

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Molecular epidemiology of enterovirus 71 infection in the Western Pacific Region. Abstract Text:

BACKGROUND: Recently, there have been large outbreaks of hand, foot and mouth disease (HFMD) mainly caused by enterovirus 71 (EV71) associated with severe neurological diseases in the Western Pacific Region (WPR). To monitor the realtime trend of EV71 transmission throughout the WPR, the authors conducted a molecular epidemiological analysis of EV71 infection. METHODS: Viruses were isolated from clinical samples from patients with HFMD or those with neurological complications. The EV71 isolates were identified by microneutralization assay. The VP4 and/or VP1 regions of recent EV71 isolates were sequenced and subjected to phylogenetic analysis using reference EV71 strains. RESULTS: The phylogenetic analysis of EV71 isolates from the WPR revealed two major genogroups, B and C, based on the nucleotide sequence alignment of the VP1 or VP4 region. These two major genogroups were further divided into subgenogroups, B1, B2, B3, and B4 and C1, C2, C3 and C4, respectively. CONCLUSIONS: The molecular epidemiological analyses of recent and previous EV71 isolates in the WPR indicated that two major genogroups of EV71 are co-circulating in Australia, Malaysia, Singapore, Taiwan and Japan. Recent EV71 isolates in Mainland China constitute a new distinct genetic cluster, subgenogroup C4. Two major lineages of EV71 are the major causative agents of the present HFMD epidemics in the WPR and both are considered to be neurovirulent.

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Molecular epidemiology of enterovirus 71 infection in the Western Pacific Region. Journal Published:

PUBLICATION TYPE: Research Support, Non-U.S. Gov

Journal: Pediatrics international : official journal of the

VOLUME: 46

Page Numbers: 231-5

Journal Abbreviation: Pediatr Int

ISSN: 1328-8067

DAY: 21

MONTH: Apr

YEAR: 2004

Molecular epidemiology of enterovirus 71 infection in the Western Pacific Region. Information

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LANGUAGE: eng

NlmUniqueID: 100886002

Molecular epidemiology of enterovirus 71 infection in the Western Pacific Region. Keywords Mesh Terms:

KEYWORDS: Thailand

MESH TERMS: epidemiology

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Grant and Affiliation Information for Molecular epidemiology of enterovirus 71 infection in the Western Pacific Region.

AFFILIATION: Department of Virology II, National Institute of Infectious Diseases, Tokyo, Japan. hshimizu@nih.go.jp

Country: Australia

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MEDLINETA: Pediatr Int

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