Molecular developmental neurobiology of formation, guidance and survival of primary vestibular neurons.

Molecular developmental neurobiology of formation, guidance and survival of primary vestibular neurons. Research Abstract Details 

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Molecular developmental neurobiology of formation, guidance and survival of primary vestibular neurons. Abstract Text:

B Fritzsch,

Untangling the molecular and physiological interactions that generate the proper connections of the primary vestibular neurons in normal gravity requires two parallel approaches. One approach needs to use mutant mice to delineate the molecular basis of developmental mechanisms that govern ear development, including formation and differentiation of neurons and establishment of their peripheral and central connections. Beyond that and in addition to it, we need physiological investigations using microgravity and/or hypergravity, as well as absence of otoconia, to understand the role played by vestibular stimuli to fine tune connections of primary and secondary vestibular neurons. This paper provides an overview of some of the molecular mechanisms uncovered over the last few years that guide development, differentiation and survival of primary vestibular neurons of the mammalian ear. Briefly, several genes that are essential for primary neuron formation have been identified, all genes that govern embryonic survival are known and the first genes and mechanisms that guide formation of proper connections are being revealed. While still incomplete, the progress has been astounding and the completion of the mouse genome project will further accelerate the pace. Such data pave the way to put the research on the influence of altered gravity stimulation within a molecular framework.

Molecular developmental neurobiology of formation, guidance and survival of primary vestibular neurons. Publishing Authors By Initials

B Fritzsch,

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Molecular developmental neurobiology of formation, guidance and survival of primary vestibular neurons. Journal Published:

PUBLICATION TYPE: Review

Journal: Advances in space research : the official journal

VOLUME: 32

Page Numbers: 1495-1500

Journal Abbreviation: Adv Space Res

ISSN: 0273-1177

DAY: 4

MONTH: 03

YEAR: 2003

Molecular developmental neurobiology of formation, guidance and survival of primary vestibular neurons. Information

Number of References: 37

LANGUAGE: eng

NlmUniqueID: 9878935

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Grant and Affiliation Information for Molecular developmental neurobiology of formation, guidance and survival of primary vestibular neurons.

AFFILIATION: Creighton U, Omaha, NE

Country: United States

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MEDLINETA: Adv Space Res

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