Molecular cytogenetic findings in a three-way novel variant of t(1;8;21)(p35;q22;q22): a unique relocation of the AML1/ETO fusion gene 1p35 in AML-M2.

Molecular cytogenetic findings in a three-way novel variant of t(1;8;21)(p35;q22;q22): a unique relocation of the AML1/ETO fusion gene 1p35 in AML-M2. Research Abstract Details 

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Molecular cytogenetic findings in a three-way novel variant of t(1;8;21)(p35;q22;q22): a unique relocation of the AML1/ETO fusion gene 1p35 in AML-M2. Abstract Text:

Firoz Ahmad,Prajakta Kokate,Pratiksha Chheda,Rupa Dalvi,Bibhu Ranjan Das,Swarna Mandava,Firoz Ahmad,Prajakta Kokate,Pratiksha Chheda,Rupa Dalvi,Bibhu Ranjan Das,Swarna Mandava,

Acute myeloid leukemia (AML) is a malignant neoplasm of hematopoietic stem cells characterized by an abnormal proliferation of myeloid precursors, a reduced rate of apoptosis, and an arrest in cellular differentiation. The present report deals with the results of hematologic, immunophenotypic, cytogenetic, fluorescence in situ hybridization (FISH), and molecular analyses of a 53-year-old female patient diagnosed with AML-M2. Cytogenetic and FISH analysis revealed a complex translocation involving three chromosomes showing t(1;8;21)(p35;q22;q22). The observation of breakpoints at 8q22 and 21q22 suggests a rearrangement of the ETO and AML1 genes, respectively. Using a dual-color FISH test with ETO and AML1 probes, an AML1/ETO fusion signal on the derivative 1p35 instead of der(8) was demonstrated. To the best of our knowledge, this is the first report about the relocation of the AML1/ETO fusion gene to the 1p35 rather than der(8), suggesting the presence of a novel variant of t(8;21)(q22;q22) in the observed patient.

Molecular cytogenetic findings in a three-way novel variant of t(1;8;21)(p35;q22;q22): a unique relocation of the AML1/ETO fusion gene 1p35 in AML-M2. Publishing Authors By Initials

F Ahmad,P Kokate,P Chheda,R Dalvi,BR Das,S Mandava,F Ahmad,P Kokate,P Chheda,R Dalvi,BR Das,S Mandava,

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Molecular cytogenetic findings in a three-way novel variant of t(1;8;21)(p35;q22;q22): a unique relocation of the AML1/ETO fusion gene 1p35 in AML-M2. Journal Published:

PUBLICATION TYPE: Journal Article

Journal: Cancer genetics and cytogenetics

VOLUME: 180

Page Numbers: 153-7

Journal Abbreviation: Cancer Genet. Cytogenet.

ISSN: 0165-4608

DAY: 15

MONTH: Jan

YEAR: 2008

Molecular cytogenetic findings in a three-way novel variant of t(1;8;21)(p35;q22;q22): a unique relocation of the AML1/ETO fusion gene 1p35 in AML-M2. Information

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LANGUAGE: eng

NlmUniqueID: 7909240

Molecular cytogenetic findings in a three-way novel variant of t(1;8;21)(p35;q22;q22): a unique relocation of the AML1/ETO fusion gene 1p35 in AML-M2. Keywords Mesh Terms:

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Grant and Affiliation Information for Molecular cytogenetic findings in a three-way novel variant of t(1;8;21)(p35;q22;q22): a unique relocation of the AML1/ETO fusion gene 1p35 in AML-M2.

AFFILIATION: Research and Development, SRL Ranbaxy Ltd., Plot No. 124, 17th Street, MIDC, Andheri (E), Mumbai-400093, India.

Country: United States

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MEDLINETA: Cancer Genet Cytogenet

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