Molecular control of iron transport.

Molecular control of iron transport. Research Abstract Details 

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Molecular control of iron transport. Abstract Text:

Tomas Ganz,

The iron-regulatory hormone hepcidin is a 25-amino acid peptide that is synthesized in hepatocytes. Hepcidin binds to the cellular iron export channel ferroportin and causes its internalization and degradation and thereby decreases iron efflux from iron exporting tissues into plasma. By this mechanism, hepcidin inhibits dietary iron absorption, the efflux of recycled iron from splenic and hepatic macrophages, and the release of iron from storage in hepatocytes. Hepcidin synthesis is stimulated by plasma iron and iron stores and is inhibited by erythropoietic activity, ensuring that extracellular plasma iron concentrations and iron stores remain stable and the erythropoietic demand for iron is met. During inflammation, increased hepcidin concentrations cause iron sequestration in macrophages, resulting in hypoferremia and eventually anemia of inflammation. Hepcidin deficiency plays a central role in most iron overload disorders. The role of hepcidin abnormalities in anemias that are associated with renal disease and in resistance to erythropoietic therapies remains to be elucidated.

Molecular control of iron transport. Publishing Authors By Initials

T Ganz,

For similar digestive system: liver research abstracts see: digestive system: liver research

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Molecular control of iron transport. Journal Published:

PUBLICATION TYPE: Review

Journal: Journal of the American Society of Nephrology : JA

VOLUME: 18

Page Numbers: 394-400

Journal Abbreviation: J. Am. Soc. Nephrol.

ISSN: 1046-6673

DAY: 17

MONTH: 01

YEAR: 2007

Molecular control of iron transport. Information

Number of References: 59

LANGUAGE: eng

NlmUniqueID: 9013836

Molecular control of iron transport. Keywords Mesh Terms:

KEYWORDS: Liver

MESH TERMS: metabolism

Chemical & Substance for Abstract: Molecular control of iron transport. Information

Substance Name: Iron

Registry Number: 7439-89-6

Grant and Affiliation Information for Molecular control of iron transport.

AFFILIATION: Departments of Medicine and Pathology, David Geffen School of Medicine, 10833 Le Conte Avenue, CHS 37-055, University of California, Los Angeles, CA 90095-1690, USA. tganz@mednet.ucla.edu

Country: United States

AGENCY: United States NHLBI

GRANT: HL-46809

ACRONYM: HL

MEDLINETA: J Am Soc Nephrol

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