Molecular characterization of a variant rhinovirus from an outbreak associated with uncommonly high mortality.

Molecular characterization of a variant rhinovirus from an outbreak associated with uncommonly high mortality. Research Abstract Details 

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Molecular characterization of a variant rhinovirus from an outbreak associated with uncommonly high mortality. Abstract Text:

David Kiang,Shigeo Yagi,Katherine A Kantardjieff,Euna J Kim,Janice K Louie,David P Schnurr,

BACKGROUND: Human rhinoviruses (HRVs) are the most frequent cause of acute upper respiratory tract infection, however, they are also known to replicate in the lower respiratory tract and associate with more severe respiratory illnesses. An outbreak of HRV occurred in a long-term facility in Santa Cruz, California with unusually high morbidity and mortality. OBJECTIVES: To identify viral characteristics associated with this unique outbreak, genetic relationships between these clinical isolates (SCRVs) and prototype strains of rhinovirus were investigated. STUDY DESIGN: Sequence homology and phylogenetic analyses of the SCRV VP4/VP2 region were performed in conjunction with all HRV prototypes. Due to the importance of the 5'noncoding region (NCR) and the structural genes to viral replication and host immune responses, respectively, we focused on a segment of the HRV genome which includes these regions. Molecular models of SCRV were also assessed. RESULTS: SCRV showed closest similarity to HRV82 with some divergence from the prototype. Amino acid differences were concentrated within predicted neutralization epitopes within VP2, VP3 and VP1. CONCLUSION: Sequence analyses and differences in cell culture growth characteristics suggest that this virus is a variant of HRV which has distinctive properties from its respective prototype strain.

Molecular characterization of a variant rhinovirus from an outbreak associated with uncommonly high mortality. Publishing Authors By Initials

D Kiang,S Yagi,KA Kantardjieff,EJ Kim,JK Louie,DP Schnurr,

For similar proteins: viral proteins research abstracts see: proteins: viral proteins research

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Molecular characterization of a variant rhinovirus from an outbreak associated with uncommonly high mortality. Journal Published:

PUBLICATION TYPE: Research Support, Non-U.S. Gov

Journal: Journal of clinical virology : the official public

VOLUME: 38

Page Numbers: 227-37

Journal Abbreviation: J. Clin. Virol.

ISSN: 1386-6532

DAY: 2

MONTH: 02

YEAR: 2007

Molecular characterization of a variant rhinovirus from an outbreak associated with uncommonly high mortality. Information

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LANGUAGE: eng

NlmUniqueID: 9815671

Molecular characterization of a variant rhinovirus from an outbreak associated with uncommonly high mortality. Keywords Mesh Terms:

KEYWORDS: Viral Proteins

MESH TERMS: genetics

Chemical & Substance for Abstract: Molecular characterization of a variant rhinovirus from an outbreak associated with uncommonly high mortality. Information

Substance Name: viral protein 1, rhinovirus

Registry Number: 0

Grant and Affiliation Information for Molecular characterization of a variant rhinovirus from an outbreak associated with uncommonly high mortality.

AFFILIATION: Viral and Rickettsial Disease Laboratories, California State Department of Health Services, 850 Marina Bay Parkway, Richmond, CA 94804, USA. dkiang@dhs.ca.gov

Country: Netherlands

AGENCY: United States NIAID

GRANT: AI-50496

ACRONYM: AI

MEDLINETA: J Clin Virol

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