Molecular character of the recombinant antitumor lectin from the edible mushroom Agrocybe aegerita.

Molecular character of the recombinant antitumor lectin from the edible mushroom Agrocybe aegerita. Research Abstract Details 

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Molecular character of the recombinant antitumor lectin from the edible mushroom Agrocybe aegerita. Abstract Text:

Na Yang,Xin Tong,Ye Xiang,Ying Zhang,Yi Liang,Hui Sun,Da-Cheng Wang,

The lectin from Agrocybe aegerita (AAL) has been found to possess potent tumor-suppressing function and tumor cell apoptosis-inducing activity. In this paper, we report the full sequence, the active expression of the gene encoding AAL at a high level and bioassay of the binding property with lactose, apoptosis-inducing activity and DNase activity of recombinant AAL (rAAL). The results reveal that AAL is a member of the galectin family and the dimeric form is the active unit for the functional performance. The rAAL showed comparable tumor cell apoptosis-inducing activity with the wild AAL but no DNase activity at all. The molecular characters revealed by this study are significant for the in-depth investigation of the functional mechanism of this interesting protein.

Molecular character of the recombinant antitumor lectin from the edible mushroom Agrocybe aegerita. Publishing Authors By Initials

N Yang,X Tong,Y Xiang,Y Zhang,Y Liang,H Sun,DC Wang,

For similar biochemical phenomena, metabolism, and nutrition: biochemical phenomena: structure-activity relationship research abstracts see: biochemical phenomena, metabolism, and nutrition: biochemical phenomena: structure-activity relationship research

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Molecular character of the recombinant antitumor lectin from the edible mushroom Agrocybe aegerita. Journal Published:

PUBLICATION TYPE: Research Support, Non-U.S. Gov

Journal: Journal of biochemistry

VOLUME: 138

Page Numbers: 145-50

Journal Abbreviation: J. Biochem.

ISSN: 0021-924X

DAY: 19

MONTH: Aug

YEAR: 2005

Molecular character of the recombinant antitumor lectin from the edible mushroom Agrocybe aegerita. Information

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LANGUAGE: eng

NlmUniqueID: 376600

Molecular character of the recombinant antitumor lectin from the edible mushroom Agrocybe aegerita. Keywords Mesh Terms:

KEYWORDS: Structure-Activity Relationship

MESH TERMS: pharmacology

Chemical & Substance for Abstract: Molecular character of the recombinant antitumor lectin from the edible mushroom Agrocybe aegerita. Information

Substance Name: Deoxyribonucleases

Registry Number: EC 3.1.-

Grant and Affiliation Information for Molecular character of the recombinant antitumor lectin from the edible mushroom Agrocybe aegerita.

AFFILIATION: Center for Structural and Molecular Biology, Institute of Biophysics, Chinese Academy of Science, Beijing.

Country: Japan

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MEDLINETA: J Biochem

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ACCESSION NUMBER: Q6WY08

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