Molecular basis of vertebrate endoderm development.

Molecular basis of vertebrate endoderm development. Research Abstract Details 

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Molecular basis of vertebrate endoderm development. Abstract Text:

Aaron M Zorn,James M Wells,

The embryonic endoderm gives rise to the epithelial lining of the digestive and respiratory systems and organs such as the thyroid, lungs, liver, gallbladder, and pancreas. Studies in Xenopus, zebrafish, and mice have revealed a conserved molecular pathway controlling vertebrate endoderm development. The TGFbeta/Nodal signaling pathway is at the top of this molecular hierarchy and controls the expression of a number of key transcription factors including Mix-like homeodomain proteins, Gata zinc finger factors, Sox HMG domain proteins, and Fox forkhead factors. Here we review the function of these molecules comparing and contrasting their roles in each model organism. Finally, we will describe how our understanding of the molecular pathway governing endoderm development in embryos is being used to differentiate embryonic stem cells in vitro along endodermal lineages, with the ultimate goal of making therapeutically useful tissue.

Molecular basis of vertebrate endoderm development. Publishing Authors By Initials

AM Zorn,JM Wells,

For similar animals: chordata: vertebrates: fishes: cypriniformes: cyprinidae: zebrafish research abstracts see: animals: chordata: vertebrates: fishes: cypriniformes: cyprinidae: zebrafish research

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Molecular basis of vertebrate endoderm development. Journal Published:

PUBLICATION TYPE: Review

Journal: International review of cytology

VOLUME: 259

Page Numbers: 49-111

Journal Abbreviation:

ISSN: 0074-7696

DAY: 3

MONTH: 12

YEAR: 2007

Molecular basis of vertebrate endoderm development. Information

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LANGUAGE: eng

NlmUniqueID: 2985180

Molecular basis of vertebrate endoderm development. Keywords Mesh Terms:

KEYWORDS: Zebrafish

MESH TERMS: metabolism

Chemical & Substance for Abstract: Molecular basis of vertebrate endoderm development. Information

Substance Name: Transcription Factors

Registry Number: 0

Grant and Affiliation Information for Molecular basis of vertebrate endoderm development.

AFFILIATION: Division of Developmental Biology, Cincinnati Children's Hospital Research, Foundation and University of Cincinnati College of Medicine, Cincinnati, Ohio 45229, USA.

Country: United States

AGENCY: United States NICHD

GRANT: HD42572

ACRONYM: HD

MEDLINETA: Int Rev Cytol

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