Molecular basis of hepatic fibrosis.

Molecular basis of hepatic fibrosis. Research Abstract Details 

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Molecular basis of hepatic fibrosis. Abstract Text:

Alex Y Hui,Scott L Friedman,Alex Y Hui,Scott L Friedman,

Hepatic fibrosis is a wound-healing response to chronic liver injury, which if persistent can lead to cirrhosis and liver failure. Activation of hepatic stellate cells (HSCs), leading to accumulation of extracellular matrix, is the central event of fibrogenesis. Exciting progress has been made in understanding the molecular basis of this process. Major advances include: (1) elucidation of the effects (and signalling pathways) of key cytokines on HSCs; (2) understanding the transcriptional regulation of HSC activation; (3) characterisation of matrix proteases and their inhibitors; (4) demonstration of apoptosis as an important event in the resolution of hepatic fibrosis, and identification of its mediators;(5) elucidation of the complex and dynamic interaction between HSCs and matrix; and (6) understanding the role of other cellular elements in hepatic fibrosis and their interaction with HSCs. Ongoing research with gene analysis using cDNA or oligonucleotide microarrays, or transcriptional profiling, will further increase our knowledge of the regulation of the process. Ultimately,advances in the understanding of the molecular biology of hepatic fibrosis are critical to the development of effective, targeted antifibrotic therapy that might benefit millions of patients with chronic liver disease worldwide.

Molecular basis of hepatic fibrosis. Publishing Authors By Initials

AY Hui,SL Friedman,AY Hui,SL Friedman,

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Molecular basis of hepatic fibrosis. Journal Published:

PUBLICATION TYPE: Review

Journal: Expert reviews in molecular medicine

VOLUME: 5

Page Numbers: 1-23

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ISSN: 1462-3994

DAY: 14

MONTH: 02

YEAR: 2003

Molecular basis of hepatic fibrosis. Information

Number of References: 156

LANGUAGE: eng

NlmUniqueID: 100939725

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Grant and Affiliation Information for Molecular basis of hepatic fibrosis.

AFFILIATION: Division of Liver Diseases, Mount Sinai School of Medicine, 1425 Madison Avenue, Room 11-76, New York, NY 10029-6574, USA. alexyhui@hotmail.com

Country: England

AGENCY: United States NIDDK

GRANT: DK56621

ACRONYM: DK

MEDLINETA: Expert Rev Mol Med

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