Molecular architecture of the cannabinoid signaling system in the core of the nucleus accumbens.

Molecular architecture of the cannabinoid signaling system in the core of the nucleus accumbens. Research Abstract Details 

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Molecular architecture of the cannabinoid signaling system in the core of the nucleus accumbens. Abstract Text:

Ferenc ,Masahiko Watanabe,Ken Mackie, Katona, Freund,

Several abused drugs are known to alter glutamatergic signaling in reward pathways of the brain, and these plastic changes may contribute to the establishment of addiction-related behaviour. Glutamatergic synapses of the prefrontal cortical projections to the nucleus accumbens (nAcb)--which are suggested to be under endocannabinoid (eCB) control - play a central role in the addiction process. The most abundant eCB in the brain is 2-arachi-donoyl-glycerol (2-AG). It is synthesized by diacylglycerol lipase alpha (DGL-alpha), and exerts its action via type 1 cannabinoid receptors (CB1). However, the precise localization of DGL-alpha and CB1 - i.e. the sites of synthesis and action of 2AG - is still unknown. At the light microscopic level, immunocytochemistry revealed a granular pattern of DGL-alpha distribution in the core of the nAcb. Electron microscopic analysis confirmed that these granules corresponded to the heads of dendritic spines. On the other hand, presynaptic axon terminals forming excitatory synapses on these spineheads were found to express CB1 receptors. Our results demonstrate that the molecular constituents for a retrograde endocannabinoid control of glutamatergic transmission are available in the core of the nAcb, and their relative subcellular location is consistent with a role of 2-AG in addiction-related plasticity of cortical excitatory synapses in this reward area.

Molecular architecture of the cannabinoid signaling system in the core of the nucleus accumbens. Publishing Authors By Initials

F ,M Watanabe,K Mackie,I Katona,TF Freund,

For similar disorders of environmental origin: substance-related disorders research abstracts see: disorders of environmental origin: substance-related disorders research

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Molecular architecture of the cannabinoid signaling system in the core of the nucleus accumbens. Journal Published:

PUBLICATION TYPE: Research Support, Non-U.S. Gov

Journal: Ideggyógyászati szemle

VOLUME: 60

Page Numbers: 187-91

Journal Abbreviation:

ISSN: 0019-1442

DAY: 30

MONTH: Mar

YEAR: 2007

Molecular architecture of the cannabinoid signaling system in the core of the nucleus accumbens. Information

Number of References:

LANGUAGE: eng

NlmUniqueID: 17510500

Molecular architecture of the cannabinoid signaling system in the core of the nucleus accumbens. Keywords Mesh Terms:

KEYWORDS: Substance-Related Disorders

MESH TERMS: metabolism

Chemical & Substance for Abstract: Molecular architecture of the cannabinoid signaling system in the core of the nucleus accumbens. Information

Substance Name: Lipoprotein Lipase

Registry Number: EC 3.1.1.34

Grant and Affiliation Information for Molecular architecture of the cannabinoid signaling system in the core of the nucleus accumbens.

AFFILIATION: Institute of Experimental Medicine, Hungarian Academy of Sciences, Budapest.

Country: Hungary

AGENCY: United States NINDS

GRANT: NS30549

ACRONYM: NS

MEDLINETA: Ideggyogy Sz

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