Molecular and clinical perspectives of polyomaviruses: emerging evidence of importance in non-kidney transplant populations.

Molecular and clinical perspectives of polyomaviruses: emerging evidence of importance in non-kidney transplant populations. Research Abstract Details 

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Molecular and clinical perspectives of polyomaviruses: emerging evidence of importance in non-kidney transplant populations. Abstract Text:

Regis A Vilchez,Shimon Kusne,

JC virus (JCV), BK virus (BKV) and simian virus 40 (SV40) are deoxyribonucleic acid (DNA) viruses, members of the family Polyomaviridae. These viruses establish persistent infections, and reactivate from latency in their host under immunosuppression. During the last few years there has been recognition of the morbidity related to polyomaviruses, particularly BKV in kidney transplant recipients. More importantly, recent studies indicate the potential implication of JCV, BKV, and SV40 in renal dysfunction among nonrenal organ transplant patients. Polyomaviruses are tumor-inducing viruses and animal models have provided evidence of the oncogenicity of these pathogens. Although data are not conclusive, molecular studies suggest an association of BKV and SV40 with malignancies among solid organ transplant patients. As new and potent immunosuppressive agents are introduced into clinical practice, it is believed that the incidence of polyomavirus-related diseases in organ transplantation might increase. This review evaluates the biologic and epidemiologic features of these 3 viruses, the data regarding their infections in nonkidney organ transplant patients and describes future directions in the management and research of these opportunistic pathogens.

Molecular and clinical perspectives of polyomaviruses: emerging evidence of importance in non-kidney transplant populations. Publishing Authors By Initials

RA Vilchez,S Kusne,

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Molecular and clinical perspectives of polyomaviruses: emerging evidence of importance in non-kidney transplant populations. Journal Published:

PUBLICATION TYPE: Review

Journal: Liver transplantation : official publication of th

VOLUME: 12

Page Numbers: 1457-63

Journal Abbreviation: Liver Transpl.

ISSN: 1527-6465

DAY: 3

MONTH: Oct

YEAR: 2006

Molecular and clinical perspectives of polyomaviruses: emerging evidence of importance in non-kidney transplant populations. Information

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LANGUAGE: eng

NlmUniqueID: 100909185

Molecular and clinical perspectives of polyomaviruses: emerging evidence of importance in non-kidney transplant populations. Keywords Mesh Terms:

KEYWORDS: Transplants

MESH TERMS: adverse effects

Chemical & Substance for Abstract: Molecular and clinical perspectives of polyomaviruses: emerging evidence of importance in non-kidney transplant populations. Information

Substance Name: Immunosuppressive Agents

Registry Number: 0

Grant and Affiliation Information for Molecular and clinical perspectives of polyomaviruses: emerging evidence of importance in non-kidney transplant populations.

AFFILIATION: Department of Molecular Virology and Microbiology, Baylor College of Medicine, Houston, TX, USA.

Country: United States

AGENCY: United States NCI

GRANT: CA104818

ACRONYM: CA

MEDLINETA: Liver Transpl

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