Molecular and cell biology of brain tumor stem cells: lessons from neural progenitor/stem cells.

Molecular and cell biology of brain tumor stem cells: lessons from neural progenitor/stem cells. Research Abstract Details 

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Molecular and cell biology of brain tumor stem cells: lessons from neural progenitor/stem cells. Abstract Text:

The results of studies conducted in the past several years have suggested that malignant brain tumors may harbor a small fraction of tumor-initiating cells that are likely to cause tumor recurrence. These cells are known as brain tumor stem cells (BTSCs) because of their multilineage potential and their ability to self-renew in vitro and to recapitulate original tumors in vivo. The understanding of BTSCs has been greatly advanced by knowledge of neural progenitor/stem cells (NPSCs), which are multipotent and self-renewing precursor cells for neurons and glia. In this article, the authors summarize evidence that genetic mutations that deregulate asymmetric cell division by affecting cell polarity, spindle orientation, or cell fate determinants may result in the conversion of NPSCs to BTSCs. In addition, they review evidence that BTSCs and normal NPSCs may reside in similar vascularized microenvironments, where similar evolutionarily conserved signaling pathways control their proliferation. Finally, they discuss preliminary evidence that mechanisms of BTSC-associated infiltrativeness may be similar to those underlying the migration of NPSCs and neurons.

Molecular and cell biology of brain tumor stem cells: lessons from neural progenitor/stem cells. Publishing Authors By Initials

For similar cells: stem cells: pluripotent stem cells research abstracts see: cells: stem cells: pluripotent stem cells research

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Molecular and cell biology of brain tumor stem cells: lessons from neural progenitor/stem cells. Journal Published:

PUBLICATION TYPE: Review

Journal: Neurosurgical focus

VOLUME: 24

Page Numbers: E25

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ISSN: 1092-0684

DAY: 17

MONTH: 04

YEAR: 2008

Molecular and cell biology of brain tumor stem cells: lessons from neural progenitor/stem cells. Information

Number of References: 87

LANGUAGE: eng

NlmUniqueID: 100896471

Molecular and cell biology of brain tumor stem cells: lessons from neural progenitor/stem cells. Keywords Mesh Terms:

KEYWORDS: Pluripotent Stem Cells

MESH TERMS: physiology

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Grant and Affiliation Information for Molecular and cell biology of brain tumor stem cells: lessons from neural progenitor/stem cells.

AFFILIATION: Department of Neurosurgery, Boston University School of Medicine, Boston, Massachusetts 02118, USA. zhigang.xie@bmc.org

Country: United States

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MEDLINETA: Neurosurg Focus

REFSOURCE: Neurosurg Focus. 2008;24(3-4):E26; discu

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