Molecular and biochemical characterization of kettin in Caenorhabditis elegans.

Molecular and biochemical characterization of kettin in Caenorhabditis elegans. Research Abstract Details 

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Molecular and biochemical characterization of kettin in Caenorhabditis elegans. Abstract Text:

Shoichiro Ono,Kurato Mohri,Kanako Ono,

Kettin is a unique member of the connectin/titin family of muscle elastic proteins, which has repetitive immunoglobulin-like domains that are separated by weakly conserved linker sequences. In striated muscles of insects and crayfish, kettin binds to actin filaments and localizes to the Z-disc and its adjacent region in the I-band. Recent sequence analysis of invertebrate connectin/titin (also known as SLS proteins) has revealed that kettin is a splice variant of connectin/titin. In contrast, in the nematode Caenorhabditis elegans, the kettin gene is independent of the genes for other connectin/titin-related proteins. Immunofluorescent localization of kettin shows that it localizes to the I-bands in the obliquely striated body wall muscle. Therefore, C. elegans is an attractive model system to study specific functions of kettin in muscle cells.

Molecular and biochemical characterization of kettin in Caenorhabditis elegans. Publishing Authors By Initials

S Ono,K Mohri,K Ono,

For similar proteins: cytoskeletal proteins: vinculin research abstracts see: proteins: cytoskeletal proteins: vinculin research

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MEDLINE DATE:

Molecular and biochemical characterization of kettin in Caenorhabditis elegans. Journal Published:

PUBLICATION TYPE: Research Support, N.I.H., Extr

Journal: Journal of muscle research and cell motility

VOLUME: 26

Page Numbers: 449-54

Journal Abbreviation: J. Muscle Res. Cell. Motil.

ISSN: 0142-4319

DAY: 3

MONTH: 12

YEAR: 2005

Molecular and biochemical characterization of kettin in Caenorhabditis elegans. Information

Number of References:

LANGUAGE: eng

NlmUniqueID: 8006298

Molecular and biochemical characterization of kettin in Caenorhabditis elegans. Keywords Mesh Terms:

KEYWORDS: Vinculin

MESH TERMS: metabolism

Chemical & Substance for Abstract: Molecular and biochemical characterization of kettin in Caenorhabditis elegans. Information

Substance Name: Vinculin

Registry Number: 125361-02-6

Grant and Affiliation Information for Molecular and biochemical characterization of kettin in Caenorhabditis elegans.

AFFILIATION: Department of Pathology, Emory University, Whitehead Research Building, Atlanta, Georgia 30322, USA. sono@emory.edu

Country: Netherlands

AGENCY: United States NIAMS

GRANT: R01 AR48615

ACRONYM: AR

MEDLINETA: J Muscle Res Cell Motil

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