Molecular analysis of SmFes, a tyrosine kinase of Schistosoma mansoni orthologous to the members of the Fes/Fps/Fer family.

Molecular analysis of SmFes, a tyrosine kinase of Schistosoma mansoni orthologous to the members of the Fes/Fps/Fer family. Research Abstract Details 

Research Abstract Table of Contents

Jump to the:

Molecular analysis of SmFes, a tyrosine kinase of Schistosoma mansoni orthologous to the members of the Fes/Fps/Fer family. Abstract Text:

Fernanda Ludolf,Diana Bahia,Luiza F Andrade,Alexandre Cousin,Monique Capron,Colette Dissous,Raymond J Pierce,Guilherme Oliveira,

A novel protein tyrosine kinase (PTK) was identified in Schistosoma mansoni and designated SmFes. SmFes exhibits the characteristic features of Fes/Fps/Fer (fes, feline sarcoma; fps, Fujinami poultry sarcoma; fer, fes related) PTKs, containing three coiled-coil regions, an SH2 (Src-homology-2) and a TK (tyrosine kinase catalytic) domain signature. SmFes is the first gene from the Fes/Fps/Fer family identified in S. mansoni, and is a single copy gene. Phylogenetic analyses revealed that SmFes is most closely related to its invertebrate orthologues. The assembly of the SmFes cDNA and genomic sequences indicated the presence of 18 introns in SmFes. Comparison of its genomic structure with those of human Fps/Fes and Drosophila Fps indicates that intron positions are conserved within the region encoding the kinase domain. Analysis of partial cDNA clones showed the presence of a 9 bp insertion at the 3' end of exon 10, producing two different cDNA populations, pointed as an alternative splicing event. In addition, an allele of SmFes containing a 15 bp insertion was observed in the genomic sequence. Quantitative RT-PCR indicated that the overall transcription level of SmFes is rather low in all parasite developmental stages. Moreover, SmFes mRNA levels decrease progressively after cercarial transformation, consistent with a role for the corresponding protein in the early stages of infection.

Molecular analysis of SmFes, a tyrosine kinase of Schistosoma mansoni orthologous to the members of the Fes/Fps/Fer family. Publishing Authors By Initials

F Ludolf,D Bahia,LF Andrade,A Cousin,M Capron,C Dissous,RJ Pierce,G Oliveira,

For similar biochemical phenomena, metabolism, and nutrition: biochemical phenomena: sequence homology: sequence homology, nucleic acid research abstracts see: biochemical phenomena, metabolism, and nutrition: biochemical phenomena: sequence homology: sequence homology, nucleic acid research

PUBMED ID PMID:

MEDLINE DATE:

Molecular analysis of SmFes, a tyrosine kinase of Schistosoma mansoni orthologous to the members of the Fes/Fps/Fer family. Journal Published:

PUBLICATION TYPE: Research Support, Non-U.S. Gov

Journal: Biochemical and biophysical research communication

VOLUME: 360

Page Numbers: 163-72

Journal Abbreviation: Biochem. Biophys. Res. Commun.

ISSN: 0006-291X

DAY: 14

MONTH: 06

YEAR: 2007

Molecular analysis of SmFes, a tyrosine kinase of Schistosoma mansoni orthologous to the members of the Fes/Fps/Fer family. Information

Number of References:

LANGUAGE: eng

NlmUniqueID: 372516

Molecular analysis of SmFes, a tyrosine kinase of Schistosoma mansoni orthologous to the members of the Fes/Fps/Fer family. Keywords Mesh Terms:

KEYWORDS: Sequence Homology, Nucleic Acid

MESH TERMS: genetics

Chemical & Substance for Abstract: Molecular analysis of SmFes, a tyrosine kinase of Schistosoma mansoni orthologous to the members of the Fes/Fps/Fer family. Information

Substance Name: Protein-Tyrosine Kinases

Registry Number: EC 2.7.1.112

Grant and Affiliation Information for Molecular analysis of SmFes, a tyrosine kinase of Schistosoma mansoni orthologous to the members of the Fes/Fps/Fer family.

AFFILIATION: Centro de Pesquisas René Rachou-FIOCRUZ, Av. Augusto de Lima 1715, Belo Horizonte, MG 30190-002, Brazil.

Country: United States

AGENCY: United States FIC

GRANT: TW007012-01

ACRONYM: TW

MEDLINETA: Biochem Biophys Res Commun

REFSOURCE:

DATABASENAME:

ACCESSION NUMBER:

Number Hits: 0

Molecular analysis of SmFes, a tyrosine kinase of Schistosoma mansoni orthologous to the members of the Fes/Fps/Fer family Related Publications

• A multiwire proportional counter for very high counting rates.
• Aluminum hydroxide associated to Schistosoma mansoni 22.6 kDa protein abrogates partial protection against experimental infection but not alter interleukin-10 production.
• Characterization of a clone from an adult worm cDNA library selected with anti-Schistosoma mansoni human antibodies dissociated from immune complexes: a preliminary report.
• Chemical and ecotoxicological characterization of ashes obtained from sewage sludge combustion in a fluidised-bed reactor.
• Combined rTPA and aspirin therapy for intracardiac thrombosis in neonates.
• Does Walk as Mean of Transportation Help to Reach the ACSM/CDC PA Recommendation?: 1376: Board #139 May 30 9:30 AM - 11:00 AM.
• GIS applications for mapping and spatial modeling of urban-use water quality: a case study in District of Cuiabá, Mato Grosso, Brazil.
• Hepatitis C risk factor for patients submitted to dialysis.
• Influence of vitamin E succinate on retinal cell survival.
• Investigating the geminal diamine intermediate of Yersinia pestis arginine decarboxylase with substrate, product, and inhibitors using single wavelength stopped-flow spectroscopy.
• Isolation and partial characterization of a biosurfactant produced by Streptococcus thermophilus A.
• Mitochondrial energy metabolism and redox state in dyslipidemias.
• Molecular analysis of SmFes, a tyrosine kinase of Schistosoma mansoni orthologous to the members of the Fes/Fps/Fer family.
• Outcome of isolated antenatal hydronephrosis: a prospective cohort study.
• Oxidative stress induced by intense and exhaustive exercise impairs murine cognitive function.
• Protein tyrosine kinases in Schistosoma mansoni.
• Selective versus non-selective culture medium for group B streptococcus detection in pregnancies complicated by preterm labor or preterm-premature rupture of membranes.
• Sexuality, vulnerability to HIV, and mental health: an ethnographic study of psychiatric institutions.
• Single nucleotide polymorphisms identification in expressed genes of Schistosoma mansoni.
• Socioeconomic and Demographic Differences in Physical Activity Level in Adults from Metropolitan Cities: 1919: Board #207 May 31 8:00 AM - 9:30 AM.
• Staging of fabry disease using renal biopsies.
• The involvement of physico-chemical interactions in the adhesion of Candida albicans and Candida dubliniensis to epithelial cells.
• Traumatic fistula between the right coronary artery and right atrial chamber.
• VP4 protein from human rhinovirus 14 is released by pressure and locked in the capsid by the antiviral compound WIN.
• [Empowerment as a way to prevent work-related health conditions in slaughterhouse workers]
• [Hospital case fatality associated with coronary angioplasty in Rio de Janeiro State, Brazil, 1999-2003]
• [Lipase/amylase ratio in biliary acute pancreatitis and alcoholic acute/acutized chronic pancreatitis]
• [Neuropsychological assessment in patients with temporal lobe epilepsy]
• [The insula and the central core concept]
• [The pterional craniotomy: step by step]