Molecular adaptations underlying susceptibility and resistance to social defeat in brain reward regions.

Molecular adaptations underlying susceptibility and resistance to social defeat in brain reward regions. Research Abstract Details 

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Molecular adaptations underlying susceptibility and resistance to social defeat in brain reward regions. Abstract Text:

Vaishnav Krishnan,Ming-Hu Han,Danielle L Graham,Olivier Berton,William Renthal,Scott J Russo,Quincey Laplant,Ami Graham,Michael Lutter,Diane C Lagace,Subroto Ghose,Robin Reister,Paul Tannous,Thomas A Green,Rachael L Neve,Sumana Chakravarty,Arvind Kumar,Amelia J Eisch,David W Self,Francis S Lee,Carol A Tamminga,Donald C Cooper,Howard K Gershenfeld,Eric J Nestler,Vaishnav Krishnan,Ming-Hu Han,Danielle L Graham,Olivier Berton,William Renthal,Scott J Russo,Quincey Laplant,Ami Graham,Michael Lutter,Diane C Lagace,Subroto Ghose,Robin Reister,Paul Tannous,Thomas A Green,Rachael L Neve,Sumana Chakravarty,Arvind Kumar,Amelia J Eisch,David W Self,Francis S Lee,Carol A Tamminga,Donald C Cooper,Howard K Gershenfeld,Eric J Nestler,

While stressful life events are an important cause of psychopathology, most individuals exposed to adversity maintain normal psychological functioning. The molecular mechanisms underlying such resilience are poorly understood. Here, we demonstrate that an inbred population of mice subjected to social defeat can be separated into susceptible and unsusceptible subpopulations that differ along several behavioral and physiological domains. By a combination of molecular and electrophysiological techniques, we identify signature adaptations within the mesolimbic dopamine circuit that are uniquely associated with vulnerability or insusceptibility. We show that molecular recapitulations of three prototypical adaptations associated with the unsusceptible phenotype are each sufficient to promote resistant behavior. Our results validate a multidisciplinary approach to examine the neurobiological mechanisms of variations in stress resistance, and illustrate the importance of plasticity within the brain's reward circuits in actively maintaining an emotional homeostasis.

Molecular adaptations underlying susceptibility and resistance to social defeat in brain reward regions. Publishing Authors By Initials

V Krishnan,MH Han,DL Graham,O Berton,W Renthal,SJ Russo,Q Laplant,A Graham,M Lutter,DC Lagace,S Ghose,R Reister,P Tannous,TA Green,RL Neve,S Chakravarty,A Kumar,AJ Eisch,DW Self,FS Lee,CA Tamminga,DC Cooper,HK Gershenfeld,EJ Nestler,V Krishnan,MH Han,DL Graham,O Berton,W Renthal,SJ Russo,Q Laplant,A Graham,M Lutter,DC Lagace,S Ghose,R Reister,P Tannous,TA Green,RL Neve,S Chakravarty,A Kumar,AJ Eisch,DW Self,FS Lee,CA Tamminga,DC Cooper,HK Gershenfeld,EJ Nestler,

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Molecular adaptations underlying susceptibility and resistance to social defeat in brain reward regions. Journal Published:

PUBLICATION TYPE: Research Support, Non-U.S. Gov

Journal: Cell

VOLUME: 131

Page Numbers: 391-404

Journal Abbreviation: Cell

ISSN: 0092-8674

DAY: 19

MONTH: Oct

YEAR: 2007

Molecular adaptations underlying susceptibility and resistance to social defeat in brain reward regions. Information

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LANGUAGE: eng

NlmUniqueID: 413066

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Grant and Affiliation Information for Molecular adaptations underlying susceptibility and resistance to social defeat in brain reward regions.

AFFILIATION: Department of Psychiatry, The University of Texas Southwestern Medical Center (UTSWMC), 5323 Harry Hines Boulevard, Dallas, TX 75390-9070, USA.

Country: United States

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MEDLINETA: Cell

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