Mold damage in homes and wheezing in infants.

Mold damage in homes and wheezing in infants. Research Abstract Details 

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Mold damage in homes and wheezing in infants. Abstract Text:

Seung-Hyun Cho,Tiina Reponen,Grace LeMasters,Linda Levin,Jian Huang,Teija Meklin,Patrick Ryan,Manuel Villareal,David Bernstein,Seung-Hyun Cho,Tiina Reponen,Grace LeMasters,Linda Levin,Jian Huang,Teija Meklin,Patrick Ryan,Manuel Villareal,David Bernstein,

BACKGROUND: In most studies that investigate the association of mold or water damage and respiratory disorders in infants, the analysis is not adjusted for exposure to house dust mite (HDM), which is also a known cause of respiratory illnesses. OBJECTIVE: To investigate the relationship between visually observable mold or water damage and HDM (Der f 1) levels and the prevalence of lower respiratory tract symptoms and allergen sensitization in infants of atopic parents as part of a prospective birth cohort study. METHODS: On-site home visits (at the infants' age of 8 months) were performed to evaluate observable mold or water damage and HDM exposure. At a clinic visit near the infant's first birthday, medical histories, including parent-reported wheezing episodes, and a skin prick test to food and 15 common aeroallergens were conducted in 640 infants. RESULTS: More than half of the homes were found to have mold or water damage, and 5% had major mold or water damage with visible mold at 0.2 m2 or more. Only 16% of homes had a HDM allergen (Der f 1) concentration of more than 2 microg/g. Major mold or water damage increased the risk of recurrent wheezing nearly 2 times in infants, 5 times in food or aeroallergen-sensitized infants, and 6 times in aeroallergen-sensitized infants. Neither visible mold or water damage nor HDM exposure was associated with sensitization to either mold or aeroallergens. CONCLUSIONS: Visible mold was shown to be a significant risk factor for recurrent wheezing in infants at high risk of developing atopic disorders, whereas HDM exposure did not significantly increase the risk.

Mold damage in homes and wheezing in infants. Publishing Authors By Initials

SH Cho,T Reponen,G LeMasters,L Levin,J Huang,T Meklin,P Ryan,M Villareal,D Bernstein,SH Cho,T Reponen,G LeMasters,L Levin,J Huang,T Meklin,P Ryan,M Villareal,D Bernstein,

For similar investigative techniques: epidemiologic methods: statistics as topic: probability: risk: risk factors research abstracts see: investigative techniques: epidemiologic methods: statistics as topic: probability: risk: risk factors research

PUBMED ID PMID:

MEDLINE DATE:

Mold damage in homes and wheezing in infants. Journal Published:

PUBLICATION TYPE: Research Support, N.I.H., Extr

Journal: Annals of allergy, asthma & immunology : official

VOLUME: 97

Page Numbers: 539-45

Journal Abbreviation: Ann. Allergy Asthma Immunol.

ISSN: 1081-1206

DAY: 3

MONTH: Oct

YEAR: 2006

Mold damage in homes and wheezing in infants. Information

Number of References:

LANGUAGE: eng

NlmUniqueID: 9503580

Mold damage in homes and wheezing in infants. Keywords Mesh Terms:

KEYWORDS: Risk Factors

MESH TERMS: immunology

Chemical & Substance for Abstract: Mold damage in homes and wheezing in infants. Information

Substance Name: Dermatophagoides farinae antigen f 1

Registry Number: EC 3.4.22.-

Grant and Affiliation Information for Mold damage in homes and wheezing in infants.

AFFILIATION: Department of Environmental Health, University of Cincinnati, Cincinnati, Ohio 45267-0056, USA.

Country: United States

AGENCY: United States NIEHS

GRANT: R01 ES11170

ACRONYM: ES

MEDLINETA: Ann Allergy Asthma Immunol

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