Modulation of the antioxidant defence as a factor in apoptosis.

Modulation of the antioxidant defence as a factor in apoptosis. Research Abstract Details 

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Modulation of the antioxidant defence as a factor in apoptosis. Abstract Text:

M M Briehl,A F Baker,

This review focuses on evidence that oxidative stress during apoptosis is controlled, at least in part, by modulating cellular antioxidant defences. Evidence is presented from studies of apoptosis induced by glucocorticoids, HIV-1 infection and tumour necrosis factor-alpha. Glucocorticoid treatment of murine lymphocyte cell lines leads to the down-regulation of primary antioxidant defence enzymes, including catalase, superoxide dismutases, thioredoxin and DT-diaphorase. Following HIV-1 infection, disturbances in glutathione metabolism are seen, and decreased antioxidant enzyme activities have been reported for HIV-1-infected cell lines. The viral protein Tat may mediate these effects. Cellular resistance to apoptosis induced by tumour necrosis factor-alpha is modulated by the expression of manganese superoxide dismutase or Bcl-2. The loss of antioxidant defences is predicted to lead to oxidative stress, which could contribute to the mechanism of apoptosis through an effect on redox-sensitive transcription factors, calcium homeostasis or cysteine proteases.

Modulation of the antioxidant defence as a factor in apoptosis. Publishing Authors By Initials

MM Briehl,AF Baker,

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Modulation of the antioxidant defence as a factor in apoptosis. Journal Published:

PUBLICATION TYPE: Journal Article

Journal: Cell death and differentiation

VOLUME: 3

Page Numbers: 63-70

Journal Abbreviation: Cell Death Differ.

ISSN: 1350-9047

DAY: 20

MONTH: Jan

YEAR: 1996

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LANGUAGE: eng

NlmUniqueID: 9437445

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Grant and Affiliation Information for Modulation of the antioxidant defence as a factor in apoptosis.

AFFILIATION: Department of Pathology, University of Arizona, Tucson.

Country: England

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MEDLINETA: Cell Death Differ

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