Modulation of radiation-induced biochemical alterations in mice by rosemary (Rosemarinus officinalis) extract.

Modulation of radiation-induced biochemical alterations in mice by rosemary (Rosemarinus officinalis) extract. Research Abstract Details 

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Modulation of radiation-induced biochemical alterations in mice by rosemary (Rosemarinus officinalis) extract. Abstract Text:

Dhanraj Soyal,Archana Jindal,Inder Singh,P K Goyal,

Radioprotective effect of leaves extract of Rosemarinus officinalis (ROE) has been studied against 6 Gy gamma-radiations in the liver of Swiss albino mice at various post-irradiation intervals between 12 h and 30 days. In control animals (without ROE treated irradiated), an elevation in glycogen, protein, acid and alkaline contents was found till day 5th, but thereafter decreased at successive intervals without returning to normal. Cholesterol level was found to be lower than normal till 10th day, then increased up to 20th day but later declined without restoring normal level. A similar trend of variation in these biochemical parameters was observed in experimental group (ROE pretreated irradiated) also but to a lower extent. ROE significantly delayed and inhibited the rise in these biochemical parameters. Almost normal values of such constituents were regained by day 30th in experimental animals; whereas in control animals, normal values were not ever attained. In control animals, there was an elevation in lipid peroxidation (LPx) and a decrease in glutathione (GSH) in blood and liver; whereas in experimental group, decline in LPx accompanied by an increase in GSH concentration was observed.

Modulation of radiation-induced biochemical alterations in mice by rosemary (Rosemarinus officinalis) extract. Publishing Authors By Initials

D Soyal,A Jindal,I Singh,PK Goyal,

For similar plants: plant families and groups: angiosperms: lamiaceae: rosmarinus research abstracts see: plants: plant families and groups: angiosperms: lamiaceae: rosmarinus research

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Modulation of radiation-induced biochemical alterations in mice by rosemary (Rosemarinus officinalis) extract. Journal Published:

PUBLICATION TYPE: Journal Article

Journal: Phytomedicine : international journal of phytother

VOLUME: 14

Page Numbers: 701-5

Journal Abbreviation: Phytomedicine

ISSN: 0944-7113

DAY: 12

MONTH: 04

YEAR: 2007

Modulation of radiation-induced biochemical alterations in mice by rosemary (Rosemarinus officinalis) extract. Information

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LANGUAGE: eng

NlmUniqueID: 9438794

Modulation of radiation-induced biochemical alterations in mice by rosemary (Rosemarinus officinalis) extract. Keywords Mesh Terms:

KEYWORDS: Rosmarinus

MESH TERMS: therapeutic use

Chemical & Substance for Abstract: Modulation of radiation-induced biochemical alterations in mice by rosemary (Rosemarinus officinalis) extract. Information

Substance Name: Glutathione

Registry Number: 70-18-8

Grant and Affiliation Information for Modulation of radiation-induced biochemical alterations in mice by rosemary (Rosemarinus officinalis) extract.

AFFILIATION: Radiation and Cancer Biology Laboratory, Department of Zoology, University of Rajasthan, Jaipur 302004, India.

Country: Germany

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MEDLINETA: Phytomedicine

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