Modulation of murine EL-4 thymic lymphoma cell proliferation and cytokine production by vitamin E succinate.

Modulation of murine EL-4 thymic lymphoma cell proliferation and cytokine production by vitamin E succinate. Research Abstract Details 

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Modulation of murine EL-4 thymic lymphoma cell proliferation and cytokine production by vitamin E succinate. Abstract Text:

W Yu,B G Sanders,K Kline,

RRR-alpha-tocopheryl succinate (VES) was studied for effects on murine EL-4 cell proliferation and production of interleukin-2 (IL-2) and transforming growth factor-beta (TGF-beta). VES was biphasic in its actions: 0.1 microgram/ml enhanced EL-4 cell proliferation, whereas 10-20 microgram/ml inhibited cellular proliferation. Cell-conditioned media (CM) from EL-4 cells treated with 0.2 ng/ml phorbol myristate acetate (PMA) + 0.1 microgram/ml VES contained increased amounts of IL-2, as determined by the murine cytotoxic T cell IL-2-dependent CTLL-2 bioassay. VES at 0.1 microgram/ml or 0.1 microgram/ml VES + 0.2 ng/ml PMA induced the expression of IL-2 mRNA by EL-4 cells three to nine hours after treatment. CM from EL-4 cells treated with VES at 10-20 microgram/ml exhibited potent antiproliferative activity when tested in the TGF-beta-responsive mink lung cell (Mv1Lu) bioassay and showed reduced inhibitory effects when tested on TGF-beta receptor-negative mink lung (DRA-27) cells. CM from control-treated EL-4 cells exhibited no antiproliferative activity. The VES-induced antiproliferative activity was characterized as TGF-beta by neutralization analyses and immunoprecipitation of metabolically labeled proteins with TGF-beta-specific reagents. VES treatment of EL-4 cells had no effect on TGF-beta 1 mRNA expression while downregulating TGF-beta 3 mRNA expression. In summary, these studies showed that 0.1 microgram/ml VES enhanced cellular proliferation, in part, via increased IL-2 production, whereas 10-20 micrograms/ml VES inhibited cellular proliferation, in part, via the secretion of biologically active TGF-beta.

Modulation of murine EL-4 thymic lymphoma cell proliferation and cytokine production by vitamin E succinate. Publishing Authors By Initials

W Yu,BG Sanders,K Kline,

For similar heterocyclic compounds: heterocyclic compounds, 2-ring: benzopyrans: vitamin e research abstracts see: heterocyclic compounds: heterocyclic compounds, 2-ring: benzopyrans: vitamin e research

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Modulation of murine EL-4 thymic lymphoma cell proliferation and cytokine production by vitamin E succinate. Journal Published:

PUBLICATION TYPE: Research Support, Non-U.S. Gov

Journal: Nutrition and cancer

VOLUME: 25

Page Numbers: 137-49

Journal Abbreviation:

ISSN: 0163-5581

DAY: 19

MONTH: 11

YEAR: 1996

Modulation of murine EL-4 thymic lymphoma cell proliferation and cytokine production by vitamin E succinate. Information

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LANGUAGE: eng

NlmUniqueID: 7905040

Modulation of murine EL-4 thymic lymphoma cell proliferation and cytokine production by vitamin E succinate. Keywords Mesh Terms:

KEYWORDS: Vitamin E

MESH TERMS: pharmacology

Chemical & Substance for Abstract: Modulation of murine EL-4 thymic lymphoma cell proliferation and cytokine production by vitamin E succinate. Information

Substance Name: tocopherol succinate

Registry Number: 17407-37-3

Grant and Affiliation Information for Modulation of murine EL-4 thymic lymphoma cell proliferation and cytokine production by vitamin E succinate.

AFFILIATION: Genetics Institute, University of Texas, Austin 78712, USA.

Country: UNITED STATES

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MEDLINETA: Nutr Cancer

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