Modulation of hTREK-1 by carbon monoxide.

Modulation of hTREK-1 by carbon monoxide. Research Abstract Details 

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Modulation of hTREK-1 by carbon monoxide. Abstract Text:

TREK-1 is a background K channel important in the regulation of neuronal excitability. Here, we demonstrate that recombinant human TREK-1 is activated by low concentrations of carbon monoxide (CO) and nitric oxide (NO), applied via their respective donor molecules. Related channels hTASK-1 and hTASK-3 were unaffected by CO. Effects of both CO and NO were prevented by preincubation of cells with the protein kinase G inhibitor, Rp-8-Br-PET-cGMPS. The effects of CO were independent of NO formation. At higher concentrations, both NO and CO were inhibitory. As both NO and CO are important neuronal gasotransmitters and TREK is crucial in regulating neuronal excitability, our results provide a novel means by which these gases may modulate neuronal activity.

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Modulation of hTREK-1 by carbon monoxide. Journal Published:

PUBLICATION TYPE: Journal Article

Journal: Neuroreport

VOLUME: 19

Page Numbers: 345-8

Journal Abbreviation: Neuroreport

ISSN: 0959-4965

DAY: 12

MONTH: Feb

YEAR: 2008

Modulation of hTREK-1 by carbon monoxide. Information

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LANGUAGE: eng

NlmUniqueID: 9100935

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Grant and Affiliation Information for Modulation of hTREK-1 by carbon monoxide.

AFFILIATION: Faculty of Medicine and Health, University of Leeds, Leeds LS2 9JT, UK.

Country: England

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MEDLINETA: Neuroreport

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