Modulation of CaV2.3 Calcium Channel Currents by Eugenol.

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Modulation of CaV2.3 Calcium Channel Currents by Eugenol. Abstract Text:

G Chung,J N Rhee,S J Jung,J S Kim,S B Oh,G Chung,J N Rhee,S J Jung,J S Kim,S B Oh,

Eugenol, a natural congener of capsaicin, is a routine analgesic agent in dentistry. We have recently demonstrated the inhibition of Ca(V)2.2 calcium channel and sodium channel currents to be molecular mechanisms underlying the analgesic effect of eugenol. We hypothesized that Ca(V)2.3 channels are also modulated by eugenol and investigated its mode of action using the whole-cell patch-clamp technique in a heterologous expression system. Eugenol inhibited calcium currents in the E52 cell line, stably expressing the human Ca(V)2.3 calcium channels, where TRPV1 is not endogenously expressed. The extent of current inhibition was not significantly different between naïve E52 cells and TRPV1-expressing E52 cells, suggesting no involvement of TRPV1. In contrast, TRPV1 activation is prerequisite for the inhibition of Ca(V)2.3 calcium channels by capsaicin. The results indicate that eugenol has mechanisms distinct from those of capsaicin for modulating Ca(V)2.3 channels. We suggest that inhibition of Ca(V)2.3 channels by eugenol might contribute to its analgesic effect.

Modulation of CaV2.3 Calcium Channel Currents by Eugenol. Publishing Authors By Initials

G Chung,JN Rhee,SJ Jung,JS Kim,SB Oh,G Chung,JN Rhee,SJ Jung,JS Kim,SB Oh,

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Modulation of CaV2.3 Calcium Channel Currents by Eugenol. Journal Published:

PUBLICATION TYPE: Journal Article

Journal: Journal of dental research

VOLUME: 87

Page Numbers: 137-41

Journal Abbreviation: J. Dent. Res.

ISSN: 0022-0345

DAY: 25

MONTH: Feb

YEAR: 2008

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LANGUAGE: eng

NlmUniqueID: 354343

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AFFILIATION: Department of Physiology, School of Dentistry and Dental Research Institute, Seoul National University, 28-2 Yeongeon-Dong Chongno-Ku, Seoul, 110-749, Korea; and.

Country: United States

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MEDLINETA: J Dent Res

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