Modulation of biological regulatory networks during nephrogenesis.

Modulation of biological regulatory networks during nephrogenesis. Research Abstract Details 

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Modulation of biological regulatory networks during nephrogenesis. Abstract Text:

Kenneth S Ramos,M Hadi Falahatpisheh,Adrian Nanez,Qiang He,

Mesenchymal-to-epithelial transition is an important biological event during the course of renal cell differentiation as condensing mesenchyme gives rise to tubuloepithelial structures. Wilms' tumor suppressor gene (Wt1) has been identified as a master regulator of the complex genetic events that mediate mesenchymal transdifferentiation. Evidence is summarized here showing that the tightly regulated series of genetic and biochemical events during nephrogenesis is disrupted by superactivation of aryl hydrocarbon receptor (Ahr) by benzo(a)pyrene (BaP), a ubiquitous polycyclic aromatic hydrocarbon and renal carcinogen (Falahatpisheh and Ramos, 2003). Nephron formation is inhibited by BaP, a response that involves inhibition of metanephric cell differentiation and shifts in the relative abundance of Wt1 splice variants. A systems biology paradigm that combined approaches from genomics, transcriptomics, and bioinformatics revealed that the global response of murine metanephric cultures to BaP involves downregulation of Ahr and disruption of downstream targets of Wt1. Discrete networks of genetic regulation were resolved using Boolean idealizations and included genes involved in renal cell differentiation and metabolic control. This work has established a role for Ahr in renal cell differentiation and kidney development and resolved putative molecular interactions between Ahr and Wt1.

Modulation of biological regulatory networks during nephrogenesis. Publishing Authors By Initials

KS Ramos,M Hadi Falahatpisheh,A Nanez,Q He,

For similar proteins: receptors, cytoplasmic and nuclear: receptors, aryl hydrocarbon research abstracts see: proteins: receptors, cytoplasmic and nuclear: receptors, aryl hydrocarbon research

PUBMED ID PMID:

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Modulation of biological regulatory networks during nephrogenesis. Journal Published:

PUBLICATION TYPE: Review

Journal: Drug metabolism reviews

VOLUME: 38

Page Numbers: 677-83

Journal Abbreviation: Drug Metab. Rev.

ISSN: 0360-2532

DAY: 3

MONTH: 12

YEAR: 2006

Modulation of biological regulatory networks during nephrogenesis. Information

Number of References: 31

LANGUAGE: eng

NlmUniqueID: 322067

Modulation of biological regulatory networks during nephrogenesis. Keywords Mesh Terms:

KEYWORDS: Receptors, Aryl Hydrocarbon

MESH TERMS: physiology

Chemical & Substance for Abstract: Modulation of biological regulatory networks during nephrogenesis. Information

Substance Name: Receptors, Aryl Hydrocarbon

Registry Number: 0

Grant and Affiliation Information for Modulation of biological regulatory networks during nephrogenesis.

AFFILIATION: Department of Biochemistry and Molecular Biology, Center for Genetics and Molecular Medicine, University of Louisville School of Medicine, Louisville, KY 40292, USA. kenneth.ramos@louisville.edu

Country: United States

AGENCY: United States NIEHS

GRANT: ES04917

ACRONYM: ES

MEDLINETA: Drug Metab Rev

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