Modification of sialic acid carboxyl group of ganglioside.

Modification of sialic acid carboxyl group of ganglioside. Research Abstract Details 

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Modification of sialic acid carboxyl group of ganglioside. Abstract Text:

S Handa,K Nakamura,

A simple and quantitative method for the modification of sialic acid carboxyl group in ganglioside is described. Methyl iodide was added to the ganglioside in dimethylsulfoxide. The reaction was completed quickly at room temperature, giving the methyl ester with practically no by-products. Reduction of the methyl ester was achieved by sodium borohydride. These modified gangliosides were chemically characterized. Reduced GM1 has a strong antigenicity compared with the original GM1, and it raised high titer antisera which did not crossreact with the original GM1 nor with its methyl ester. Peanut agglutinin, which binds strongly to asialo GM1 but weakly to GM1, bound to the methyl ester of GM1 and reduced GM1. Cholera toxin, which is specific for GM1, also reacted with the methyl ester of GM1 and reduced GM1 to a certain extent.

Modification of sialic acid carboxyl group of ganglioside. Publishing Authors By Initials

S Handa,K Nakamura,

For similar nervous system diseases: central nervous system diseases: brain diseases: brain diseases, metabolic: brain diseases, metabolic, inborn: lysosomal storage diseases, nervous system: sphingolipidoses: gangliosidoses: gangliosidoses, gm2: tay-sachs disease research abstracts see: nervous system diseases: central nervous system diseases: brain diseases: brain diseases, metabolic: brain diseases, metabolic, inborn: lysosomal storage diseases, nervous system: sphingolipidoses: gangliosidoses: gangliosidoses, gm2: tay-sachs disease research

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Modification of sialic acid carboxyl group of ganglioside. Journal Published:

PUBLICATION TYPE: Research Support, Non-U.S. Gov

Journal: Journal of biochemistry

VOLUME: 95

Page Numbers: 1323-9

Journal Abbreviation: J. Biochem.

ISSN: 0021-924X

DAY: 19

MONTH: May

YEAR: 1984

Modification of sialic acid carboxyl group of ganglioside. Information

Number of References:

LANGUAGE: eng

NlmUniqueID: 376600

Modification of sialic acid carboxyl group of ganglioside. Keywords Mesh Terms:

KEYWORDS: Tay-Sachs Disease

MESH TERMS: metabolism

Chemical & Substance for Abstract: Modification of sialic acid carboxyl group of ganglioside. Information

Substance Name: Cholera Toxin

Registry Number: 9012-63-9

Grant and Affiliation Information for Modification of sialic acid carboxyl group of ganglioside.

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Country: JAPAN

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MEDLINETA: J Biochem

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